Jean-Claude Bradley

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Over 80% of people with social anxiety disorder (SAD) do not receive any type of treatment, despite the existence of effective evidence-based treatments. Barriers to treatment include lack of trained therapists (particularly in nonmetropolitan areas), logistical difficulties (e.g., cost, time, transportation), concerns regarding social stigma, and fear of(More)
BACKGROUND The Blue Obelisk movement was established in 2005 as a response to the lack of Open Data, Open Standards and Open Source (ODOSOS) in chemistry. It aims to make it easier to carry out chemistry research by promoting interoperability between chemistry software, encouraging cooperation between Open Source developers, and developing community(More)
We report on the implementation of the Spectral Game, a web-based game where players try to match molecules to various forms of interactive spectra including 1D/2D NMR, Mass Spectrometry and Infrared spectra. Each correct selection earns the player one point and play continues until the player supplies an incorrect answer. The game is usually played using a(More)
  • Cornelius Niemeyer, Ralph L Hollis, J Bradley, Nelson, Zusammenfassung Iii Zusammenfassung
  • 2006
Preface I would like to thank Prof. Ralph Hollis for his guidance, his support and the opportunity to write this thesis at the Microdynamic Systems Laboratory and Prof. Bradley Nelson for his support and the opportunity to go overseas for the work on this diploma thesis. Many thanks go to Christoph Bergler for his good spirit, invaluable help and the good(More)
BACKGROUND Calculating Abraham descriptors from solubility values requires that the solute have the same form when dissolved in all solvents. However, carboxylic acids can form dimers when dissolved in non-polar solvents. For such compounds Abraham descriptors can be calculated for both the monomeric and dimeric forms by treating the polar and non-polar(More)
BACKGROUND The Abraham general solvation model can be used in a broad set of scenarios involving partitioning and solubility, yet is limited to a set of solvents with measured Abraham coefficients. Here we extend the range of applicability of Abraham's model by creating open models that can be used to predict the solvent coefficients for all organic(More)
The optimization of a Ugi reaction involving the mixing of furfurylamine, benzaldehyde, boc-glycine and t-butylisocyanide is described. Triplicate runs of 48 parallel experiments are reported, varying concentration, solvent and the excess of some of the reagents. The isolation of the product was achieved by a simple filtration and wash procedure. The(More)
The current system of dissemination of scientific data and knowledge is far less efficient than it needs to be to facilitate improved collaborative science, especially considering current publication vehicles and infrastructure. There is a growing movement promoting more Open Science with the belief that a more transparent scientific process can perform far(More)
  • Martin Oberhuber, Ralph L Hollis, J Bradley, Nelson, Zusammenfassung Iii Zusammenfassung
  • 2008
Preface The underlying project has been realized during my 6-month stay at the Robotics Institute of Carnegie Mellon University. My stay at CMU was one of the most exciting times during my studies. The project I worked on perfectly suited my interests and excited about the every days challenges I developed a passion for programming and further increased my(More)