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Ultrasonic bone cutting is a new surgical technique used in dentistry to section hard tissues without damaging adjacent soft tissues. We hypothesized that such a device could also be useful in craniofacial surgery, particularly during the removal of the superior orbital roof during craniofaciostenosis surgery. An ultrasonic device was employed in different(More)
It is well known that acoustic cavitation can facilitate the inward transport of genetic materials across cell membranes (sonoporation). However, partially due to the unstationary behavior of the initiation and leveling of cavitation, the sonoporation effect is usually unstable, especially in low intensity conditions. A system which is able to regulate the(More)
Sonodynamic toxicity has always been linked to the cavitation phenomenon. In this work, sonodynamic effect with Photofrin was evaluated with a new ultrasound device: a regulated cavitation generator. In this way, acoustic intensity was substituted with cavitation level as ultrasound parameter. Photofrin potentiated significantly the cavitation cytotoxicity(More)
As other types of otoacoustic emissions, distortion product otoacoustic emissions (DPOAEs) allow the exploration of the active cochlear mechanisms known to take place in the outer hair cell system. Most authors consider that 2f1-f2 DPOAEs are generated in a cochlear region corresponding to the geometric mean (GM) of the primary frequencies. To verify the(More)
Although segregation of both simultaneous and sequential speech items may be involved in the reception of speech in noisy environments, research on the latter is relatively sparse. Further, previous studies examining the ability of hearing-impaired listeners to form distinct auditory streams have produced mixed results. Finally, there is little work(More)
Cochlear-implant (CI) users often have difficulties perceiving speech in noisy environments. Although this problem likely involves auditory scene analysis, few studies have examined sequential segregation in CI listening situations. The present study aims to assess the possible role of fundamental frequency (F(0)) cues for the segregation of vowel(More)
Ultrasound treatment has been proposed by several authors to enhance the repair of long bone injury. The present study investigated in a murine model the treatment by low-intensity pulsed ultrasound (LIPUS) of calvarial flat bone defect. The animals were operated to create bone defect and exposed to ultrasound for 5 min per day, 5 d per week, during two(More)
Owing to the complex behavior of ultrasound-induced bubble clouds (nucleation, linear and nonlinear oscillations, collapse), acoustic cavitation remains a hardly controllable phenomenon, leading to poorly reproducible ultrasound-based therapies. A better control of the various aspects of cavitation phenomena for in vivo applications is a key requirement to(More)
Enhancing cavitation activity with minimal acoustic intensities could be interesting in a variety of therapeutic applications where mechanical effects of cavitation are needed with minimal heating of surrounding tissues. The present work focuses on the relative efficiency of a signal combining two neighbouring frequencies and a one-frequency signal for(More)
Applications involving acoustic cavitation mechanisms, such as sonoporation, are often poorly reproducible because of the unstationary behavior of cavitation. For this purpose, this study proposes to work at a fixed cavitation level instead of a fixed acoustic intensity. A regulated cavitation generator has been developed in an in vitro configuration of(More)