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  • Edward T. Parkin, Nicole T. Watt, +6 authors Nigel M. Hooper
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences
  • 2007 (First Publication: 26 June 2007)
  • Proteolytic processing of the amyloid precursor protein (APP) by β-secretase, β-site APP cleaving enzyme (BACE1), is the initial step in the production of the amyloid β (Aβ) peptide, which isExpand
  • Jean C Manson, E Jamieson, +10 authors Christopher J. Bostock
  • Biology, Medicine
  • The EMBO journal
  • 1999 (First Publication: 1 December 1999)
  • A mutation equivalent to P102L in the human PrP gene, associated with Gerstmann-Straussler syndrome (GSS), has been introduced into the murine PrP gene by gene targeting. Mice homozygous for thisExpand
  • Jean C Manson, Alan R. Clarke, Patricia A. McBride, Irene Mcconnell, Jayne Hope
  • Biology, Medicine
  • Neurodegeneration : a journal for…
  • 1994 (First Publication: 1 December 1994)
  • We have produced by gene targeting a mouse line with an inactive PrP gene. In animals heterozygous for this mutation, PrP mRNA is reduced by approximately 50% throughout the brain compared with wildExpand
  • P. Avaria Piccardo, Jean C Manson, Declan King, Bernardino F. Ghetti, Rona M. Barron
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2007 (First Publication: 13 March 2007)
  • Prion diseases or transmissible spongiform encephalopathies are characterized histopathologically by the accumulation of prion protein (PrP) ranging from diffuse deposits to amyloid plaques.Expand
  • Rona M. Barron, Susan L Campbell, +4 authors Jean C Manson
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2007 (First Publication: 7 December 2007)
  • Diagnosis of transmissible spongiform encephalopathy (TSE) disease in humans and ruminants relies on the detection in post-mortem brain tissue of the protease-resistant form of the host glycoproteinExpand