Jean C. J. Liu

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Squire et al. have proposed that trace and delay eyeblink conditioning procedures engage separate learning systems: a declarative hippocampal/cortical system associated with conscious contingency awareness, and a reflexive sub-cortical system independent of awareness, respectively (Clark and Squire, 1998; Smith et al., 2005). The only difference between(More)
STUDY OBJECTIVES We examined how sleep deprivation alters physiological responses to psychosocial stress by evaluating changes in skin conductance. DESIGN Between-subjects design with one group allocated to 24 h of total sleep deprivation and the other to rested wakefulness. SETTING The study took place in a research laboratory. PARTICIPANTS(More)
In medical research, clinical trials evaluate drug efficacy, the ability of a pharmacological product to reduce or manage clinical symptoms. However, symptomatic improvements following drug delivery can arise from: the pharmacological action of the drug (drug effect), natural improvements over time (spontaneous recovery), and patient expectations associated(More)
Previous studies with prairie voles suggest that the hormone oxytocin is crucial for bond formation - indicated when a partner preference is formed towards the target vole. In this study, we conduct the first empirical test of whether oxytocin likewise promotes partner preferences in humans. Seventy-six undergraduate students received either oxytocin or(More)
BACKGROUND Dietary disinhibition is a behavioral trait associated with weight gain and obesity. Because food choices are made according to the relative value assigned to each option, examination of valuation signals through functional magnetic resonance imaging (fMRI) may elucidate the neural basis for the association between dietary disinhibition and(More)
Research in animals and humans suggests a role of oxytocin in social approach to strangers. We tested this by introducing undergraduate students to opposite-gendered strangers, with each member of the pair having taken either oxytocin or placebo. One hundred and four undergraduate students were paired up and engaged in a face-to-face conversation structured(More)
Previous research suggests that sleep deprivation may heighten normal reactions to an aversive social encounter. In this study, we explored how 24 h of sleep deprivation may influence responses to ostracism. Ninety-six healthy young adults were randomly allocated to either the sleep-deprivation or well-rested condition, wherein they engaged in two rounds of(More)
Sleep deprivation alters decision making; however, it is unclear what specific cognitive processes are modified to drive altered choices. In this manuscript, we examined how one night of total sleep deprivation (TSD) alters economic decision making. We specifically examined changes in uncertainty preferences dissociably from changes in the strategy with(More)
Inadequate sleep and psychological stress can both elevate physiological stress markers, such as cortisol. Prior studies that have applied induced psychosocial stress after a night of experimental sleep deprivation have found these effects to be compounded. We examined whether the relationship between stress reactivity and poor sleep also extends to(More)
INTRODUCTION Incidental reports collected in clinical trials suggest that amongst participants, omega-3 fatty acids derived from fish oil ('omega-3') may be difficult to blind. MATERIALS AND METHODS We conducted a systematic evaluation of blinding success in a 24-week trial of omega-3 versus an oil-based placebo. Within 1 week of supplement commencement(More)
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