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  • Fiona L. Scott, Jean-Bernard Denault, Stefan J. Riedl, Hwain Shin, Martin Renatus, Guy S Salvesen
  • Biology, Medicine
  • The EMBO journal
  • 2005 (First Publication: 9 February 2005)
  • The X-linked inhibitor of apoptosis protein (XIAP) uses its second baculovirus IAP repeat domain (BIR2) to inhibit the apoptotic executioner caspase-3 and -7. Structural studies have demonstratedContinue Reading
  • Jean-Bernard Denault, Brendan P. Eckelman, Hwain Shin, Cristina Pop, Guy S Salvesen
  • Biology, Medicine
  • The Biochemical journal
  • 2007 (First Publication: 1 July 2007)
  • During apoptosis, the initiator caspase 9 is activated at the apoptosome after which it activates the executioner caspases 3 and 7 by proteolysis. During this process, caspase 9 is cleaved by caspaseContinue Reading