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Two roles for Rad50 in telomere maintenance
We describe two roles for the Rad50 protein in telomere maintenance and the protection of chromosome ends. Using fluorescence in situ hybridisation (FISH) and fibre‐FISH analyses, we show thatExpand
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A Recessive Founder Mutation in Regulator of Telomere Elongation Helicase 1, RTEL1, Underlies Severe Immunodeficiency and Features of Hoyeraal Hreidarsson Syndrome
Dyskeratosis congenita (DC) is a heterogeneous inherited bone marrow failure and cancer predisposition syndrome in which germline mutations in telomere biology genes account for approximatelyExpand
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ERCC1/XPF Protects Short Telomeres from Homologous Recombination in Arabidopsis thaliana
Many repair and recombination proteins play essential roles in telomere function and chromosome stability, notwithstanding the role of telomeres in “hiding” chromosome ends from DNA repair andExpand
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Two roles for Rad 50 in telomere maintenance
We describe two roles for the Rad50 protein in telomere maintenance and the protection of chromosome ends. Using fluorescence in situ hybridisation (FISH) and fibreFISH analyses, we show that absenceExpand
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TRF1 prevents permissive DNA damage response, recombination and Break Induced Replication at telomeres
Telomeres are a significant challenge to DNA replication and are prone to replication stress and telomere fragility. The shelterin component TRF1 facilitates telomere replication but the molecularExpand