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- Valérie Audinot, François Mailliet, +14 authors Jean A. Boutin
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 2003
Melatonin has a key role in the circadian rhythm relay to periphery organs. Melatonin exerts its multiple roles mainly through two seven transmembrane domain, G-coupled receptors, namely MT1 or MT2… (More)
- Gilles Ferry, Natacha Moulharat, +11 authors Jean A. Boutin
- The Journal of pharmacology and experimental…
- 2008
Autotaxin catalyzes the transformation of lyso-phosphatidylcholine in lyso-phosphatidic acid (LPA). LPA is a phospholipid possessing a large panel of activity, in particular as a motility factor or… (More)
- Z D Dang, Valérie Audinot, Socrates E Papapoulos, Jean A. Boutin, Clemens W. G. M. Löwik
- The Journal of biological chemistry
- 2003
The principal soy phytoestrogen genistein has an array of biological actions. It binds to estrogen receptor (ER) alpha and beta and has ER-mediated estrogenic effects. In addition, it has… (More)
- Jean A. Boutin, Valérie Audinot, Gilles Ferry, Philippe Delagrange
- Trends in pharmacological sciences
- 2005
Melatonin, an indoleamine neurohormone that is synthesized mainly in the pineal gland and derived from 5-HT, has many effects on a wide range of physio-pathological functions. Some of these effects… (More)
- Gilles Ferry, Sabrina Hecht, +7 authors Jean A. Boutin
- Chemico-biological interactions
- 2010
Quinone reductase 2 is a cytosolic enzyme which catalyses the reduction of quinones, such as menadione and coenzymes Q. Despite a relatively close sequence-based resemblance to NAD(P)H:quinone… (More)
- Barbara Calamini, Bernard D Santarsiero, Jean A. Boutin, Andrew D. Mesecar
- The Biochemical journal
- 2008
Melatonin exerts its biological effects through at least two transmembrane G-protein-coupled receptors, MT1 and MT2, and a lower-affinity cytosolic binding site, designated MT3. MT3 has recently been… (More)
- Gilles Ferry, Edwige Tellier, +14 authors Jean-Sébastien Saulnier-Blache
- The Journal of biological chemistry
- 2003
Our group has recently demonstrated (Gesta, S., Simon, M., Rey, A., Sibrac, D., Girard, A., Lafontan, M., Valet, P., and Saulnier-Blache, J. S. (2002) J. Lipid Res. 43, 904-910) the presence, in… (More)
- Fanny Vella, Gilles Ferry, Philippe Delagrange, Jean A. Boutin
- Biochemical pharmacology
- 2005
Quinone reductase 2 has been discovered in 1961 and rediscovered in 1997. Because of its sequence homology with quinone reductase 1, it has been suspected to detoxify quinones. Ten years later,… (More)
- Mathias Antoine, Jean A. Boutin, Gilles Ferry
- Biochemistry
- 2009
Slow conformational changes have been proposed to be responsible for the kinetic positive cooperativity of glucokinase (GK) with glucose. Induced-fit and preexisting equilibrium kinetic models have… (More)
- Olivier Nosjean, Jean A. Boutin
- Cellular signalling
- 2002
The peroxisome proliferator-activated receptor (PPAR) family was discovered from an orphan nuclear receptor approach, and thereafter, three subtypes were identified, namely PPARalpha, PPARbeta or… (More)