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- Mark John Millan, Adrian Newman-Tancredi, +9 authors Alain P Gobert
- Synapse
- 2000
Herein, we evaluate the interaction of the alpha(2)-AR antagonist, yohimbine, as compared to fluparoxan, at multiple monoaminergic receptors and examine their roles in the modulation of adrenergic,… (More)
- Valérie Audinot, François Mailliet, +14 authors Jean A. Boutin
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 2003
Melatonin has a key role in the circadian rhythm relay to periphery organs. Melatonin exerts its multiple roles mainly through two seven transmembrane domain, G-coupled receptors, namely MT1 or MT2… (More)
- Zhichao Dang, Valérie Audinot, Socrates E Papapoulos, Jean A. Boutin, Clemens W. G. M. Löwik
- The Journal of biological chemistry
- 2003
The principal soy phytoestrogen genistein has an array of biological actions. It binds to estrogen receptor (ER) alpha and beta and has ER-mediated estrogenic effects. In addition, it has… (More)
- Surajit Ganguly, J A Gastel, +11 authors David C. Klein
- Proceedings of the National Academy of Sciences…
- 2001
The daily rhythm in melatonin levels is controlled by cAMP through actions on the penultimate enzyme in melatonin synthesis, arylalkylamine N-acetyltransferase (AANAT; serotonin N-acetyltransferase,… (More)
- Gilles Ferry, Natacha Moulharat, +11 authors Jean A. Boutin
- The Journal of pharmacology and experimental…
- 2008
Autotaxin catalyzes the transformation of lyso-phosphatidylcholine in lyso-phosphatidic acid (LPA). LPA is a phospholipid possessing a large panel of activity, in particular as a motility factor or… (More)
- Gilles Ferry, Edwige Tellier, +14 authors Jean-Sébastien Saulnier-Blache
- The Journal of biological chemistry
- 2003
Our group has recently demonstrated (Gesta, S., Simon, M., Rey, A., Sibrac, D., Girard, A., Lafontan, M., Valet, P., and Saulnier-Blache, J. S. (2002) J. Lipid Res. 43, 904-910) the presence, in… (More)
- Olivier Nosjean, Myriam Ferro, +7 authors Jean A. Boutin
- The Journal of biological chemistry
- 2000
The regulation of the circadian rhythm is relayed from the central nervous system to the periphery by melatonin, a hormone synthesized at night in the pineal gland. Besides two melatonin G-coupled… (More)
- N Chartrel, Rodrigo Alvear-Perez, +11 authors C Llorens-cortes
- Science
- 2007
Zhang et al. (Research Articles, 11 November 2005, p. 996) reported that obestatin, a peptide derived from the ghrelin precursor, activated the orphan G protein-coupled receptor GPR39. However, we… (More)
- Jean A. Boutin, Valérie Audinot, Gilles Ferry, Philippe Delagrange
- Trends in pharmacological sciences
- 2005
Melatonin, an indoleamine neurohormone that is synthesized mainly in the pineal gland and derived from 5-HT, has many effects on a wide range of physio-pathological functions. Some of these effects… (More)
- F Cogé, Sophie P Guénin, +8 authors Jean Pierre Galizzi
- The Biochemical journal
- 2001
In the present paper we report the genomic organization of the human histamine H3-receptor gene, which consists of four exons spanning 5.5 kb on chromosome 20. Using PCR, six alternative splice… (More)