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Fungal mycoflora and mycotoxins in Korean polished rice destined for humans.
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.
- SangJoon Mo, Dong Hwan Kim, Y. Yoon
- Biology, ChemistryJournal of the American Chemical Society
- 2 February 2011
This unique feature of FK506 biosynthesis, in which a dedicated PKS provides an atypical extender unit for the main modular PKS, illuminates a new strategy for the combinatorial biosynthesis of designer macrolide scaffolds as well as FK505 analogues.
Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor
- SangJoon Mo, Y. Ban, Je Won Park, Young Ji Yoo, Y. Yoon
- BiologyJournal of Industrial Microbiology…
- 12 September 2009
Results show that the methylmalonyl-CoA supply is a limiting factor for FK506 biosynthesis and that among the three pathways analyzed, the MCM pathway is the most effective precursor supply pathway supporting the highest titer of Fk506 in S. clavuligerus CKD1119.
Ochratoxin A in Korean food commodities: occurrence and safety evaluation.
- Je Won Park, S. Chung, Young-bae Kim
- Biology, MedicineJournal of agricultural and food chemistry
- 1 June 2005
There is at present no considerable risk of ochratoxin A exposure for the average Korean consumer, and the estimated PDI for all Koreans fell into the range of 0.8-4.1 ng/kg bw/day, while for heavy consumers the estimates ranged from 1.7 to 9.7 ng/ kg bW/day.
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
It is discovered that the kanamycin biosynthetic pathway contains an early branch point, governed by the substrate promiscuity of a glycosyltransferase, that leads to the formation of two parallel pathways in which early intermediates are further modified.
Engineering of plant-specific phenylpropanoids biosynthesis in Streptomyces venezuelae.
Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product.
Heterologous expression of the barbamide biosynthetic gene cluster in the terrestrial actinobacterium Streptomyces venezuelae resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.
Biosynthesis of plant-specific flavones and flavonols in Streptomyces venezuelae.
- Sung Ryeol Park, J. Paik, M. Ahn, Je Won Park, Y. Yoon
- Biology, EngineeringJournal of microbiology and biotechnology
- 1 September 2010
This work expanded the applicability of the S. venezuelae system to the production of more diverse plant polyketides including flavones and flavonols.
2-Deoxystreptamine-containing aminoglycoside antibiotics: recent advances in the characterization and manipulation of their biosynthetic pathways.
- Sung Ryeol Park, Je Won Park, Y. Ban, J. Sohng, Y. Yoon
- Chemistry, BiologyNatural product reports
This work focuses on recent advances in the characterization of 2-deoxystreptamine-containing aminoglycosides and their biosynthetic enzymes and pathway as well as some chemo-enzymatic and metabolic engineering approaches for the biological production of natural, semi-synthetic, and novel aminglycosides.
A nanohybrid system for taste masking of sildenafil
- Ji-Hee Lee, Goeun Choi, J. Choy
- Materials Science, BiologyInternational journal of nanomedicine
- 26 March 2012
It is concluded that the MMT-based nanohybrid is a promising delivery system for taste masking of SDN with possibly improved drug exposure.