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  • J Yu, Y W Chien
  • 1997
Peptide and protein drugs are being used increasingly in major research and development programs in the pharmaceutical industry and are also an important class of therapeutic agents due to advances in genetic engineering and biotechnology. Systemic delivery of these macromolecular drugs, however, has been limited to the parenteral route largely because of(More)
Palabras clave: Laparoscopia. Intususcepción. Cáncer de colon. Adult intussusception is a relatively rare condition. It accounts for 1% of patients with bowel obstruction and 5-10% of all intussusceptions. We describe a case of adult intussuscep-tion of the sigmoid colon caused by malignancy which was successfully treated by laparoscopic resection. A(More)
  • Van Asperen, M Cj ; Garcia-Closas, +110 authors Julian Peto
  • 2016
identifies two additional breast cancer susceptibility loci at 9q31.2. which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract We recently identified a novel susceptibility variant, rs865686, for estrogen-receptor positive breast cancer at 9q31.2. Here, we report a fine-mapping(More)
To study the effect of respiration on transpulmonary permeation kinetics of drugs, an in vitro pulmonary permeation system, which consists of a setup for the simulation of respiratory dynamics, was developed. The system is composed offour major components: a pair of horizontal-type half-cells, a model air-blood barrier, an instrument for the application and(More)
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