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Volumetric cell densities in 13 different subfields of the temporal lobe were calculated to test various hypotheses about mesial and lateral temporal lobe sclerosis in patients with complex partial epilepsy. In patients benefitting (primary group) from anterior temporal lobectomy (ATL), sclerosis was greater (fewer cells) in anterior than in posterior(More)
Pyramidal cell densities in various regions of the anterior and posterior hippocampal formation were measured from en bloc temporal lobe resections and compared with presurgical stereoelectroencephalography (SEEG) data derived from depth electrodes in 12 patients with temporal lobe epilepsy. These data were compared with cell densities observed in four(More)
Surface and depth EEG seizure patterns were compared in 34 patients with intractable temporal lobe epilepsy in whom depth EEG electrodes had been chronically implanted in order to localize epileptogenic sites with a view to surgery. EEG records accompanied by clinical seizures, auras, no behavioral changes, as well as records for which no behavioral(More)
Depth spike activity was evaluated from medial temporal lobe sites using computer spike recognition techniques in all-night sleep records derived from 10 patients with medically refractory complex partial seizures. Sleep stages were classified into 1 of 4 groups: wakefulness, REM sleep, light sleep and deep sleep. Some disturbance in the periodicity of the(More)
The statistical properties of depth spiking in the interictal EEG were assessed in 12 patients with intractable temporal lobe epilepsy in whom electrodes had been stereotactically implanted for diagnostic purposes. Prior to the implantation surgery each patient was administered a battery of neuropsychologic tests. Correlational analyses showed that the(More)
The depth ictal electroencephalographic (EEG) propagation sequence accompanying 78 complex partial seizures of mesial temporal origin was reviewed in 24 patients (15 from the University of Pittsburgh Epilepsy Center and 9 from UCLA). All patients were monitored with bilateral mesial frontal and mesial temporal depth electrodes and later received anterior(More)
Light and electron microscopic analyses were carried out on the stimulated and unstimulated paravermal cortices of six rhesus monkeys that had electrodes implanted on their cerebella for 2 months. The electrodes and the stimulation regime (10 p.p.s.: 8 min on, 8 min off) were similar to those used to stimulate the human cerebellum for treatment of certain(More)