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The role of CYP26 enzymes in retinoic acid clearance
Retinoic acid (RA) is a critical signaling molecule that regulates gene transcription and the cell cycle. Understanding of RA signaling has increased dramatically over the past decades, but theExpand
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Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase.
Retinoic acid (RA) is a critical signaling molecule that performs multiple functions required to maintain cellular viability. It is also used in the treatment of some cancers. Enzymes in the CYP26Expand
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The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.
All-trans retinoic acid (RA) is a critical signaling molecule and its concentration is tightly regulated. Several P450 enzymes including CYP26A1, CYP2C8, and CYP3A4 have been proposed to beExpand
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Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases.
All-trans-retinoic acid (atRA) is an important signaling molecule in all chordates. The cytochrome P450 enzymes CYP26 are believed to partially regulate cellular concentrations of atRA via oxidativeExpand
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Substrate Specificity and Ligand Interactions of CYP26A1, the Human Liver Retinoic Acid Hydroxylase
All-trans-retinoic acid (atRA) is the active metabolite of vitamin A. atRA is also used as a drug, and synthetic atRA analogs and inhibitors of retinoic acid (RA) metabolism have been developed. TheExpand
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Suspected GHB overdoses in the emergency department.
Blood specimens from 146 suspected gamma-hydroxybutyrate (GHB) overdose cases, presenting to an emergency department in Washington State over a 12-month period, were analyzed for GHB and other drugs.Expand
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ROSITA II Project: Evaluation of On-Site Saliva Drug Testing Devices in Washington State
Washington State, as part of the collaborative ROSITA II project (please see group abstract), evaluated two oral fluid drug testing devices. Samples were collected from Washington State drivers whoExpand
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SOFT Special Issue of the Journal of Analytical Toxicology.
  • Jayne E Thatcher
  • Chemistry, Medicine
  • Journal of analytical toxicology
  • 1 October 2014