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- Publications
- Influence
The role of CYP26 enzymes in retinoic acid clearance
- Jayne E Thatcher, N. Isoherranen
- Biology, Medicine
- Expert opinion on drug metabolism & toxicology
- 21 July 2009
Retinoic acid (RA) is a critical signaling molecule that regulates gene transcription and the cell cycle. Understanding of RA signaling has increased dramatically over the past decades, but the… Expand
Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase.
- J. Lutz, V. Dixit, +5 authors N. Isoherranen
- Biology, Medicine
- Biochemical pharmacology
- 15 January 2009
Retinoic acid (RA) is a critical signaling molecule that performs multiple functions required to maintain cellular viability. It is also used in the treatment of some cancers. Enzymes in the CYP26… Expand
The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.
- Jayne E Thatcher, Alex Zelter, N. Isoherranen
- Biology, Medicine
- Biochemical pharmacology
- 15 September 2010
All-trans retinoic acid (RA) is a critical signaling molecule and its concentration is tightly regulated. Several P450 enzymes including CYP26A1, CYP2C8, and CYP3A4 have been proposed to be… Expand
Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases.
- Ariel R Topletz, Jayne E Thatcher, +4 authors N. Isoherranen
- Biology, Medicine
- Biochemical pharmacology
- 2012
All-trans-retinoic acid (atRA) is an important signaling molecule in all chordates. The cytochrome P450 enzymes CYP26 are believed to partially regulate cellular concentrations of atRA via oxidative… Expand
Substrate Specificity and Ligand Interactions of CYP26A1, the Human Liver Retinoic Acid Hydroxylase
- Jayne E Thatcher, Brian R Buttrick, +4 authors N. Isoherranen
- Chemistry, Medicine
- Molecular Pharmacology
- 1 August 2011
All-trans-retinoic acid (atRA) is the active metabolite of vitamin A. atRA is also used as a drug, and synthetic atRA analogs and inhibitors of retinoic acid (RA) metabolism have been developed. The… Expand
Suspected GHB overdoses in the emergency department.
- F. Couper, Jayne E Thatcher, B. Logan
- Medicine
- Journal of analytical toxicology
- 1 September 2004
Blood specimens from 146 suspected gamma-hydroxybutyrate (GHB) overdose cases, presenting to an emergency department in Washington State over a 12-month period, were analyzed for GHB and other drugs.… Expand
ROSITA II Project: Evaluation of On-Site Saliva Drug Testing Devices in Washington State
- Jayne E Thatcher
- Medicine
- 2006
Washington State, as part of the collaborative ROSITA II project (please see group abstract), evaluated two oral fluid drug testing devices. Samples were collected from Washington State drivers who… Expand
- 3
SOFT Special Issue of the Journal of Analytical Toxicology.
- Jayne E Thatcher
- Chemistry, Medicine
- Journal of analytical toxicology
- 1 October 2014