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Fibrillar alpha-synuclein is a component of the Lewy body, the characteristic neuronal inclusion of the Parkinson's disease (PD) brain. Both alpha-synuclein mutations linked to autosomal dominant early-onset forms of PD promote the in vitro conversion of the natively unfolded protein into ordered prefibrillar oligomers, suggesting that these protofibrils,(More)
In this thesis, we describe a genetic algorithm for optimizing the superpeer structure of semantic peer to peer networks. Peer to peer, also called P2P, networks enable us to search for content or information 1 in a distributed fashion across a large number of peers while providing a level of fault tolerance by preventing disconnecting peers from disrupting(More)
Image Insight Inc. recently released an Android application (GammaPix Lite™) that uses smartphone cameras for radiation detection and measurement. Given the wide diversity of smartphones in use, and the frequent release of new models, traceable calibrations of all the devices on which the app could possibly run is clearly not practical. In this(More)
PixelJunk Shooter 2 is a video game for the Playstation 3 in which the player must navigate a spaceship through a two dimensional environment, solving physics-based puzzles and rescuing survivors to progress. A key element of the game is the use of realtime fluid dynamics to simulate a range of materials (such as solids, lava, water and gases) and their(More)
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