Jayda Lee Ann Siggers

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Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in newborn premature infants. Clinical studies show increased incidence of NEC in premature infants with enteral formula feeding; however, pathogenesis remains unclear. To identify the NEC-related proteins for molecular mechanisms, we applied proteomics analysis to characterize(More)
Following preterm birth, bacterial colonization and enteral formula feeding predispose neonates to gut dysfunction and necrotizing enterocolitis (NEC), a serious gastrointestinal inflammatory disease. We hypothesized that administration of probiotics would beneficially influence early bacterial colonization, thereby reducing the susceptibility to(More)
Preterm neonates are susceptible to gastrointestinal disorders such as necrotizing enterocolitis (NEC). Maternal milk and colostrum protects against NEC via growth promoting, immunomodulatory, and antimicrobial factors. The fetal enteral diet amniotic fluid (AF), contains similar components, and we hypothesized that postnatal AF administration reduces(More)
Necrotizing enterocolitis (NEC), a serious gastrointestinal inflammatory disease, frequently occurs in preterm neonates that fail to adapt to enteral nutrition. A temporal gel-based proteomics study was performed on porcine intestine with NEC lesions induced by enteral formula feeding. Functional assignment of the differentially expressed proteins revealed(More)
Necrotizing enterocolitis (NEC) in preterm infants develops very rapidly from a mild intolerance to enteral feeding into intestinal mucosal hemorrhage, inflammation, and necrosis. We hypothesized that immediate feeding-induced gut responses precede later clinical NEC symptoms in preterm pigs. Fifty-six preterm pigs were fed total parenteral nutrition (TPN)(More)
The gastrointestinal inflammatory disorder, necrotizing enterocolitis (NEC), is among the most serious diseases for preterm neonates. Nutritional, microbiological and immunological dysfunctions all play a role in disease progression but the relationship among these determinants is not understood. The preterm gut is very sensitive to enteral feeding which(More)
OBJECTIVES Intestinal colonization challenges the neonatal innate immune system, especially in newborns with an immature immune response lacking the supportive bioactive components from mother's milk. Accordingly, formula-fed preterm pigs frequently show bacterial overgrowth, mucosal atrophy, and gut lesions reflecting necrotizing enterocolitis (NEC) within(More)
Transition from parenteral to enteral nutrition induces immediate diet1 dependent gut histological and immunological responses in preterm neonates 2 3 Jayda Siggers, Per T. Sangild, Tim K. Jensen, Richard H. Siggers, Kerstin Skovgaard, Ann 4 Cathrine F. Støy, Bent B. Jensen, Thomas Thymann, Stine B. Bering, Mette Boye 5 6 Department of Human Nutrition,(More)
Postnatal amniotic fluid intake reduces gut inflammatory responses and 1 necrotizing enterocolitis in preterm neonates 2 3 Jayda Siggers, Mette V. Østergaard, Richard H. Siggers, Kerstin Skovgaard, Lars Mølbak, 4 Thomas Thymann, Mette Schmidt, Hanne K. Møller, Stig Purup, Lisbeth N. Fink, Hanne 5 Frøkiær, Mette Boye, Per T. Sangild, Stine B. Bering 6 7 1(More)
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