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Abstract 2093: Regulation of c-Myc expression by aspirin and salicylic acid in colon cancer cells through a novel pathway
Epidemiological studies have demonstrated a significant correlation between regular aspirin use and reduced colon cancer incidence and mortality; however, the exact pathway has not been identified.Expand
Abstract A02: Cyclin A2 and CDK2 as Novel Targets of Aspirin and Salicylic acid: a Potential Role in Cancer Prevention
It is demonstrated that aspirin and salicylic acid down-regulate cyclin A2/CDK2 proteins in multiple cancer cell lines, suggesting a novel target and mechanism of action in chemoprevention. Expand
Abstract 3501: Aspirin modulates oncogene expression in hct 116 colon cancer cells
Modulation of proto oncogenes by AspirIn may represent an important pathway by which Aspirin may mediate its anti-cancer effects and is currently investigating how inhibition of c-RAF levels by Aspirationin and Salicylic acid affects downstream signaling molecules such as p42/p44 MAP kinases. Expand
Abstract 1782: Post-translational regulation of cyclins by Aspirin through 26S proteasome: Implications in chemoprevention
Recent studies have shown that, regular use aspirin for 5 years or more, decreases the occurrence of cancer of the colon, skin, breast, prostate and lung tissues. However, the mechanism of itsExpand
Abstract 4038: Aspirin acetylates p53 in colon cancer cells and induces the expression of p21 and Bax: Identification of aspirin acetylated sites on rp53
It is shown that aspirin acetylated p53 at lysine 382 in both colon cancer cells and that p53 pathway may contribute to the anti-cancer properties of aspirin. Expand
Abstract 2354: Identification of CDK1 as an aspirin and salicylic acid binding protein: a potential role in chemoprevention
Data emerging from the past 10 years have consolidated the rationale for investigating the use of aspirin for chemoprevention; however, the mechanisms leading to its anti-cancer effects are stillExpand