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We have utilized in vitro three-dimensional epithelial cell cultures to analyze the role of apoptosis in the formation and maintenance of a hollow glandular architecture. Lumen formation is associated with the selective apoptosis of centrally located cells; this apoptosis follows apicobasal polarization and precedes proliferative suppression during acinar(More)
Elevated coexpression of colony-stimulating factor receptor (CSF-1R) and its ligand, CSF-1, correlates with invasiveness and poor prognosis of a variety of epithelial tumors (Kacinski, B.M. 1995. Ann. Med. 27:79-85). Apart from recruitment of macrophages to the tumor site, the mechanisms by which CSF-1 may potentiate invasion are poorly understood. We show(More)
Activation of the serine/threonine kinase Akt/PKB positively impacts on three cellular processes relevant to tumor progression: proliferation, survival, and cell size/growth. Using a three-dimensional culture model of MCF-10A mammary cells, we have examined how Akt influences the morphogenesis of polarized epithelial structures. Activation of a(More)
An image compression method combining discrete wavelet transform (DWT) and vector quantization (VQ) is presented. First, a three-level DWT is performed on the original image resulting in ten separate subbands (ten codebooks are generated using the Self Organizing Feature Map algorithm, which are then used in Vector Quantization, of the wavelet transformed(More)
In this paper electromagnetic transient (EMT) simulation of large scale power systems using graphics processing unit (GPU) based computing is demonstrated. As the size of power system networks increases, the simulation time using conventional central processing units (CPUs) based simulation increases drastically. This paper proposes a hybrid CPU-GPU(More)
Autophagy-related (ATG) proteins have increasingly demonstrated functions other than cellular self-eating. In this issue, Mauthe et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201602046) conduct an unbiased RNA interference screen of the ATG proteome to reveal numerous noncanonical roles for ATG proteins during viral infection.
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