Jayant S . Sancheti

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In the present study, we aim to investigate the neuroprotective and neurotrophic effects of naturally occurring polyphenols like apigenin and luteolin and also to explore the underlying mechanisms with respect to Parkinson's disease (PD). MPTP (25 mg/kg) along with Probenecid (250 mg/kg) was administrated for five consecutive days to induce parkinsonism in(More)
The present study was to investigate the anticonvulsant and antiepileptogenic potential of thymol. Anticonvulsant activity of thymol (5–100 mg/kg i.p.) was studied using maximal electroshock, pentylenetetrazole (PTZ), strychnine and 4-aminopyridine (4-AP) models. Thymol at the selected dose was also studied for its effect on locomotion. Antiepileptogenic(More)
In the present study, anticonvulsant activity of methanol extract of Eclipta alba (10-200 mg/kg) was studied using pentylenetetrazole- and picrotoxin-induced seizure models. Mechanism of effect of methanol extract of Eclipta alba was further elucidated by studying its GABAA receptor modulatory activity and its effect on levels of GABA in mice brain.(More)
A new robust, simple and economic high performance thin layer chromatographic method was developed for simultaneous estimation of L-glutamic acid and γ-amino butyric acid in brain homogenate. The high performance thin layer chromatographic separation of these amino acid was achieved using n-butanol:glacial acetic acid:water (22:3:5 v/v/v) as mobile phase(More)
*Corresponding author E mail: sadhanasathaye@hotmail.com J. Pharm. BioSci. 4(2013) 149-156 Abstract Extensive studies have been done to understand the patho-phyisology of epilepsy. Inspite of large number of antiepileptic drugs being available in the market, 30% of patients still suffer from epilepsy. Various experiments have been done to explore the(More)
CONTEXT Eclipta alba (Linn) Hassk. (Asteraceae) has been reported to be a nerve tonic and has been used to treat epilepsy in folk medicine. OBJECTIVE The present study isolates and characterizes luteolin from E. alba and evaluates its antiepileptic potential in chemically induced acute and chronic models in mice. MATERIALS AND METHODS The methanol(More)
Many naturally occurring compounds are known for their therapeutic uses in epilepsy disorders. Extracts of Eclipta alba and Pistacia integerrima are known for their antiepileptic activities. Phytochemical investigations of these plants have shown presence of luteolin, α-pinene, β-pinene and terpinen-4-ol constituents, respectively. However, the(More)
Aim: The present study investigated the inhibitory effect of methanolic extract of Couroupita guianensis leaves (MCG) on carbohydrate hydrolysing enzymes and glucose uptake in isolated rat hemidiaphragm. Method: The effects of MCG at different concentrations (1.25-10mg) were carried out on carbohydrate hydrolysing enzymes namely porcine pancreatic αamylase,(More)
*Corresponding author E mail: sadhanasathaye@hotmail.com J. Pharm. BioSci. 1(2013) 76-88 Abstract Epilepsy is a disorder of central nervous system characterized by spontaneous seizures. The seizures result from neuronal hyperexcitability and hypersynchronus neuronal firing. Inspite of number of drugs available for the treatment of epilepsy approximately 30%(More)
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