Jayant S. Sancheti

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In the present study, we aim to investigate the neuroprotective and neurotrophic effects of naturally occurring polyphenols like apigenin and luteolin and also to explore the underlying mechanisms with respect to Parkinson's disease (PD). MPTP (25 mg/kg) along with Probenecid (250 mg/kg) was administrated for five consecutive days to induce parkinsonism in(More)
The present study was to investigate the anticonvulsant and antiepileptogenic potential of thymol. Anticonvulsant activity of thymol (5–100 mg/kg i.p.) was studied using maximal electroshock, pentylenetetrazole (PTZ), strychnine and 4-aminopyridine (4-AP) models. Thymol at the selected dose was also studied for its effect on locomotion. Antiepileptogenic(More)
In the present study, anticonvulsant activity of methanol extract of Eclipta alba (10-200 mg/kg) was studied using pentylenetetrazole- and picrotoxin-induced seizure models. Mechanism of effect of methanol extract of Eclipta alba was further elucidated by studying its GABAA receptor modulatory activity and its effect on levels of GABA in mice brain.(More)
Extensive studies have been done to understand the patho-phyisology of epilepsy. Inspite of large number of antiepileptic drugs being available in the market, 30% of patients still suffer from epilepsy. Various experiments have been done to explore the association of dietary supplements in relieving symptoms of epilepsy and it suggests that dietary therapy(More)
A new robust, simple and economic high performance thin layer chromatographic method was developed for simultaneous estimation of L-glutamic acid and γ-amino butyric acid in brain homogenate. The high performance thin layer chromatographic separation of these amino acid was achieved using n-butanol:glacial acetic acid:water (22:3:5 v/v/v) as mobile phase(More)
Many naturally occurring compounds are known for their therapeutic uses in epilepsy disorders. Extracts of Eclipta alba and Pistacia integerrima are known for their antiepileptic activities. Phytochemical investigations of these plants have shown presence of luteolin, α-pinene, β-pinene and terpinen-4-ol constituents, respectively. However, the(More)
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