Jayant Maini

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An enormous amount of information on a genomics scale is available for zebrafish (Danio rerio), which is a well-studied model organism for human diseases. However, a majority of this annotation is scattered in obscure data sources. There have been limited efforts to present it on a unified and integrated platform, which would help to understand the(More)
Epigenetic cellular memory mechanisms that involve polycomb and trithorax group of proteins are well conserved across metazoans. The cis-acting elements interacting with these proteins, however, are poorly understood in mammals. In a directed search we identified a potential polycomb responsive element with 25 repeats of YY1 binding motifthatwe designate(More)
The advancements in genomics technologies and the amenability to large-scale computational analysis have contributed immensely to the understanding of the zebrafish genome, its organization, and its functional correlates. Translating genomics information into biological meaning would require integration and amenability of data and tools. FishMap is a(More)
A large repertoire of gene-centric data has been generated in the field of zebrafish biology. Although the bulk of these data are available in the public domain, most of them are not readily accessible or available in nonstandard formats. One major challenge is to unify and integrate these widely scattered data sources. We tested the hypothesis that active(More)
The Polycomb/Trithorax Responsive Elements (PRE/TREs) are the cis-regulatory sequences that interact with both repressive (PcG) as well as activating (TrxG) complexes. However, most of the mammalian PREs are demonstrated to interact with the repressive polycomb (PcG) complexes only. We have carried out an unbiased search for proteins interacting with human(More)
Meghna Singh1,2,y, Deeksha Bhartiya1,2,y, Jayant Maini, Meenakshi Sharma, Angom Ramcharan Singh1,z, Subburaj Kadarkaraisamy1,z, Rajiv Rana1,z, Ankit Sabharwal1,2,z, Srishti Nanda3,z, Aravindhakshan Ramachandran1,z, Ashish Mittal1,z, Shruti Kapoor1,2,z, Paras Sehgal1,z, Zainab Asad1,2,z, Kriti Kaushik1,2,z, Shamsudheen Karuthedath Vellarikkal1,2,z, Divya(More)
Meghna Singh1,2,y, Deeksha Bhartiya1,2,y, Jayant Maini, Meenakshi Sharma, Angom Ramcharan Singh1,z, Subburaj Kadarkaraisamy1,z, Rajiv Rana1,z, Ankit Sabharwal1,2,z, Srishti Nanda3,z, Aravindhakshan Ramachandran1,z, Ashish Mittal1,z, Shruti Kapoor1,2,z, Paras Sehgal1,z, Zainab Asad1,2,z, Kriti Kaushik1,2,z, Shamsudheen Karuthedath Vellarikkal1,2,z, Divya(More)
Epigenetic modulation captures the lack of correlation between the genotype and the phenotype. It also provides an interface between environment and the genotype leading to functional plasticity of the genome. While drug response can be modulated by the epigenome, the therapeutic intervention by drugs can also be considered as an environmental cue for(More)
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