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The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity.
Osteoarthritis (OA) is the most prevalent and debilitating joint disease, and there are currently no effective disease-modifying treatments available. Multiple risk factors for OA, such as aging,Expand
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The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration
Objectives The circadian clocks are internal timing mechanisms that drive ∼24-hour rhythms in a tissue-specific manner. Many aspects of the physiology of the intervertebral disc (IVD) show clearExpand
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The U5 snRNA Internal Loop 1 Is a Platform for Brr2, Snu114 and Prp8 Protein Binding During U5 snRNP Assembly
The U5 small nuclear ribonucleoprotein particle (snRNP) forms the heart of the spliceosome which is required for intron removal from pre‐mRNA. The proteins Prp8, Snu114 and Brr2 all assemble with theExpand
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Androgens influence expression of matrix proteins and proteolytic factors during cutaneous wound healing
Excessive proteolytic activity is a feature of chronic wounds such as venous ulcers, in which resolution of the inflammatory response fails and restorative matrix accumulation is delayed as aExpand
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Sex dimorphism in wound healing: the roles of sex steroids and macrophage migration inhibitory factor.
That endogenous sex steroid hormones profoundly influence the response to cutaneous injury is well established. How they and other factors combine to direct repair in male and female animals is muchExpand
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5alpha-dihydrotestosterone (DHT) retards wound closure by inhibiting re-epithelialization.
The ongoing search for explanations as to why elderly males heal acute skin wounds more slowly than do their female counterparts (and are more strongly disposed to conditions of chronic ulceration)Expand
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Inside Lab Invest
The healing of skin wounds is significantly delayed in the elderly, with aged men being at greater risk of developing chronic venous ulcers than their female counterparts. Studies have suggested thatExpand