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Eomesodermin (Eomes), a T-bet homologue expressed in activated CD8+T cells was recently proposed to act as a master regulator of cytotoxic CD8+ T cell effector function and offers an exciting avenue for future exploration. Here, we have identified and characterized the full-length Atlantic salmon Eomes cDNA (2477 bp). Promoter analysis of the salmon Eomes(More)
In silico alanine scanning mutagenesis on the cleavable isoform of mucin 1 revealed isoleucine 67 as one of the key factors contributing to the strain at the autoproteolytic cleavage site. In this study, we demonstrate the structural basis of isoleucine-induced rigidity towards the strain-driven autoproteolysis at G−1S+1 cleavage site of mucin 1. We further(More)
Lectins play important role in innate immunity of animals. The affinity of the natural haemagglutinin of the giant freshwater prawn Macrobrachium rosenbergii towards vertebrate erythrocytes and its level with relation to sex, size and moult stages were studied. The strongest agglutinating titres in haemolymph of prawns were marked against guinea pig,(More)
The T-box transcription factor T-bet is expressed in a number of hematopoietic cell types in mammals and plays an essential role in the lineage determination of Th1 T-helper cells and is considered as an essential feature for both innate and adaptive immune responses in higher vertebrates. In the present study, we have identified and characterized the(More)
In privacy preserving data mining, utility mining plays an important role. In privacy preserving utility mining, some sensitive itemsets are hidden from the database according to certain privacy policies. Hiding sensitive itemsets from the adversaries is becoming an important issue nowadays. Also, only very few methods are available in the literature to(More)
Cell-mediated immunity (CMI) is one of the important effector arms during immunological responses to infection and vaccine development. Therefore, a key challenge in developing new vaccines that are effective involves the induction of optimal memory T cell responses [1]. This requires a better understanding of the mechanisms and signals involved in the(More)
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