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This paper proposes a new adaptable FPGA logic element based on fracturable 6-LUTs, which fundamentally alters the longstanding belief that a 4-LUT is the most efficient area/delay tradeoff. We will describe theory and benchmarking results showing a 15% performance increase with 12% area decrease vs. a standard BLE4. The ALM structure is one of a number of(More)
This paper describes the Altera Stratix II™ logic and routing architecture. This architecture features a novel adaptive logic module (ALM) that is based on a 6-LUT, but can be partitioned into two smaller LUTs to efficiently implement circuits containing a range of LUT sizes that arises in conventional synthesis flows. This provides a performance(More)
Structured ASICs have emerged as a mid-way between cell-based ASICs with high NRE costs and FPGAs with high unit costs. Though the structured ASIC fabric attacks mask and other fixed cost it does not solve verification, particularly physical verification issues with ASICs or logic errors missed by simulation which would require re-spins. These can be(More)
As programmable logic grows more viable for implementing full design systems, performance has become a primary issue for programmable logic device architectures. This paper presents the high-level design of Dali, a PLD architecture specifically aimed at performance-driven applications. We will present significant portions of the background research that(More)
Architects of programmable logic devices (PLDs) face several challenges when optimizing a new device family for low manufacturing cost. When given an aggressive die-size goal, functional blocks that seem otherwise insignificant become targets for area reduction. Once low die cost is achieved, it is seen that testing and packaging costs must be considered.(More)
Structured-ASIC design provides a mid-way point between FPGA and cell-based ASIC design for performance, area and power, but suffers from the same increasing verification burden associated with cell-based design. In this paper we address the verification issue with a methodology and fabric to directly tie FPGA prototype and functional in-system verification(More)
First-line sequential high dose chemotherapy is under investigation in patients with "poor prognosis" metastatic germ cell tumours in order to improve survival. Despite the use of autologous peripheral blood stem cell transplantation and granulocyte colony stimulating factor chemotherapy dose intensification is associated with severe haematotoxicity(More)
BACKGROUND The current two studies evaluate the feasibility, toxicity and efficacy of an adjuvant combined modality treatment strategy containing a three to four-drug chemotherapy regimen plus 5-fluorouracil (FU)-based radiochemotherapy. PATIENTS AND METHODS Between December 2000 and October 2003, a total of 86 patients were included in both studies.(More)
BACKGROUND We assessed the efficacy of amifostine for protection from chemotherapy-induced toxicities in patients treated with conventional-dose paclitaxel, ifosfamide, cisplatin (TIP) and high-dose carboplatin, etoposide and thiotepa (CET) followed by peripheral blood progenitor cell (PBPC) rescue. PATIENTS AND METHODS In a prospective single-center(More)
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