Jay Patrick

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The mesolimbic dopamine (DA) pathway plays an integral role in the reinforcing properties of many drugs of abuse, including alcohol (ethanol/EtOH). It has been reported that selective and acute blockade of the DA D3 receptor by SB-277011A will attenuate EtOH preference, intake, and lick responses in EtOH preferring rats. However, alcohol consumption that(More)
The functional properties of acetylcholine receptors are altered during the development of Xenopus myotomal muscle. A similar change also occurs in dissociated cell cultures of embryonic myotomal muscle. Metabolism of acetylcholine receptors was examined in order to ascertain whether the turnover rate changed at a time when the functional changes were(More)
Five undernourished children with severe cerebral palsy (CP) were tube-fed sufficient volumes of Isocal to allow rapid weight gain. Isocal provided, on average, 88% of their daily energy intake for at least 25 days. The purpose of our study was to correct the undernutrition and to analyze the major erythrocyte phospholipids before and after feeding periods(More)
1. The consequences of incubating liposomes with rat thymocytes have been studied using liposomes of dipalmitolyphosphatidylcholine and cholesterol or dipalmitoylphosphatidylcholine only. 2. Dipalmitoylphosphatidylcholine-cholesterol liposomes do not bind to the cells can be removed by washing. An increase in cellular cholesterol is observed. However(More)
  • 1965
When the major portion of a weight-bearing joint such as the ankle is fractured and displacement occurs, accurate reduction is essential if late osteoarthritic changes are to be avoided. In many trimalleolar fractures the posterior malleolar fragment is small and simple manipulative treatment and plaster fixation is satisfactory. If, however, the posterior(More)