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Gel formation and spatial structure is an important area of study in polymer physics and in macromolecular and cellular biophysics. Agarose has a sufficiently complex gelation mechanism to make it an interesting prototype for many other gelling systems, including those involved in amyloid fibrillogenesis. Static (over a scattering vector range of 0.1-30(More)
The formation of insulin amyloid fibrils is important not only for the development of reliable drugs but also for modeling the basic properties of protein self-assembly. Fibrillation kinetics is typically characterized by an initial apparent lag phase related to the formation of oligomers, protofibrils, and aggregation nuclei. Afterwards, aggregation(More)
Static and dynamic light scattering were used to investigate the effects of L-arginine, commonly used to inhibit protein aggregation, on the initial aggregation kinetics of solutions of bovine insulin in 20% acetic acid and 0.1 M NaCl as a model system for amyloidosis. Measurements were made as a function of insulin concentration (0.5-2.0 mM), quench(More)
A. Abate, F. Abdalla, S. Allam, S. Allen, R. Ansari, S. Bailey, W. Barkhouse, T. Beers, M. Blanton, M. Brodwin, J. Brownstein, R. Brunner, M. Carrasco-Kind, J. Cervantes-Cota, E. Chisari, M. Colless, J. Comparat, J. Coupon, E. Cheu, C. Cunha, A. de la Macorra, I. Dell’Antonio, B. Frye, E. Gawiser, N. Gehrels, K. Grady, A. Hagen, P. Hall, A. Hearin, H.(More)
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