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We have implemented an unbiased cell morphology-based screen to identify small-molecule modulators of cellular processes using the Cytometrix (TM) automated imaging and analysis system. This assay format provides unbiased analysis of morphological effects induced by small molecules by capturing phenotypic readouts of most known classes of pharmacological(More)
The near-field optical interaction between a sharp probe and a sample of interest can be exploited to image, spectroscopically probe, or modify surfaces at a resolution (down to approximately 12 nm) inaccessible by traditional far-field techniques. Many of the attractive features of conventional optics are retained, including noninvasiveness, reliability,(More)
In near-field scanning optical microscopy, a light source or detector with dimensions less than the wavelength (lambda) is placed in close proximity (lambda/50) to a sample to generate images with resolution better than the diffraction limit. A near-field probe has been developed that yields a resolution of approximately 12 nm ( approximately lambda/43) and(More)
Recent developments in optical studies of single molecules at room temperature are reviewed, with an emphasis on the underlying principles and the potential of single-molecule experiments. Examples of single-molecule studies are given, including photophysics and photochemistry pertinent to single-molecule measurements, spectral fluctuations, Raman(More)
We demonstrate that sub-wavelength optical images borne on partially-spatially-incoherent light can be recovered, from their far-field or from the blurred image, given the prior knowledge that the image is sparse, and only that. The reconstruction method relies on the recently demonstrated sparsity-based sub-wavelength imaging. However, for(More)
  • Susanne C Kehr, Pu Yu, Yongmin M Liu, Markus Parzefall, Asif I Khan, Rainer Jacob +150 others
  • 2011
Superlenses create sub-diffraction-limit images by reconstructing the evanescent fields arising from an object. We study the lateral, vertical, and spectral field distribution of three different perovskite-based superlenses by means of scattering-type near-field microscopy. Sub-diffraction-limit resolution is observed for all samples with an image contrast(More)
  • J R Sheats, H Antoniadis, M Hueschen, W Leonard, J Miller, R Moon +30 others
height. Assuming a linear relationship between thickness and absorption, as well as assuming a direct relationship between absorption and emission, the fluorescence signal, measured by NSOM, is expected to increase by the same percentage. The increase in fluorescence between the tallest feature and the background signal of 13 kcps is 13 kcps. Although this(More)
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