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The Secure Virtual Enclaves (SVE) collaboration infrastructure allows multiple organizations to share their distributed application objects, while respecting organizational autonomy over local resources. The infrastructure is transparent to applications, which may be accessed via a web server, or may be based on Java or Microsoft's DCOM. The SVE(More)
Receptor activator of NF-kappaB ligand (RANKL) and interferon gamma (IFN-gamma) are critical and opposing mediators of osteoclastogenesis, exerting stimulatory and inhibitory effects, respectively. Cathepsin K (CTSK) is a secreted protease that plays an essential role in osteoclastic bone resorption. We have examined the role of IFN-gamma in the regulation(More)
Noninbred Sprague-Dawley rats were maintained on a choline-deficient diet containing 0.05% ethionine. After 10-13 weeks, livers were dispersed with collagenase, lysozyme, collagenase and hyaluronidase. Pronase, or a selected batch of trypsin. The highest yield of cells with histochemically demonstrable gamma-glutamyl transpeptidase (GGT) was obtained with(More)
The Ontology Definition Metamodel (ODM) 1 has been used as a basis for ontology development as well as for generation of OWL ontologies and Java-based production rules that together form a part of the run-time fabric of a context-aware application. Issues encountered in ODM-based ontology, source code and rules generation highlight the need for enhancements(More)
Many previous studies have shown that a proportion of patients with carcinoma of the prostate have increased activity of the creatine kinase (E.C. isoenzyme designated BB in sera from their peripheral blood. We have analyzed tissues from prostatic hyperplasia of 22 patients and from prostatic carcinoma of 23 additional patients. Prostatic(More)
Numerous RDF vocabularies and OWL, KIF, and other knowledge representation language ontologies have been contributed to the growing body of ontologies available in the public domain over the last ten years. Many of these were created with government-funded research support in the US and EU. Only a small subset is reusable, and fewer are appropriate for use(More)
A consensus peptide sequence, QSYP, appears as an artifact during the mapping of monoclonal antibodies (MAbs) using a random peptide phage display library. Phage bearing this QSYP sequence were independently selected by four different laboratories screening separate MAb preparations with the same phage library. In each case, the QSYP sequence was selected(More)