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Delta-9-tetrahydrocannabinol (THC) is frequently found in the blood of drivers involved in automobile accidents, and marijuana use has been associated with impaired field sobriety test performance. The present study used a within-subject design to compare the effects of marijuana (0, 1.77, or 3.95% THC) on equilibrium and simulated driving. Ten marijuana(More)
The extent to which caffeine antagonizes alcohol-induced impairment of simulated automobile driving at the current lowest legal American limit (0.08% BrAC) was the focus of this study. Fifteen adults swallowed a capsule (0, 200, or 400 mg caffeine) then drank a beverage (0.0 or 0.6 g/kg ethanol) in a within-subject, double-blind, randomized procedure.(More)
BACKGROUND The effects of alcohol on simple versus complex psychomotor performance were compared in 18 adults. METHODS Subjects received ethanol doses of 0.0, 0.5, and 0.8 g/kg in a randomized, double-blind, within-subject design. Forty minutes after finishing their drinking, the subjects completed a 60-min battery of tests that included: 1) a sensory(More)
Kainic acid (KA) (10(-6)-10(-8) M) reversibly depolarized CA3 pyramidal cells when applied topically to the apical dendritic area of these cells in the hippocampal slice. The magnitude of membrane depolarization and the time to recovery of resting membrane potential were concentration-related. Application of 10(-5) M KA produced complete membrane(More)
The influences of morphine and opioid peptides on hippocampal CA1 pyramidal cells were investigated using intracellular recordings from the in vitro slice preparation. Morphine applied to somal and basal dendritic areas of CA1 cells via a pressure ejection system confirmed a number of excitatory actions of opiates and opioid peptides in this brain region.(More)
The delusional misidentification syndrome (DMS) has been associated with a range of neurological conditions. Three cases of DMS in patients with Parkinson's disease and dementia, treated with dopaminergic medications, are presented. It is postulated that DMS associated with parkinsonism results from a combination of dopaminergic psychosis and cognitive(More)
Averaged sensory-evoked potentials were recorded from the outer molecular layer of the dentate gyrus in naïve rats and in rats conditioned to respond in the presence of an auditory stimulus. Two components (negative peaks) of the potentials were functionally distinguished in terms of responsiveness to unique or conditioned auditory stimuli. Each component(More)
Three digital mucous cysts and three dorsal wrist ganglia were studied by light and scanning electron microscopy. Both exhibited the same findings, namely a porous network of collagenous fibers forming the wall and a fibrillated inner surface composed of a random arrangement of collagen fibers. An intermittent thin membrane was observed on the inner(More)
The effects of morphine, diazepam and three neuroleptic agents (chloropromazine, perphenazine and haloperiodol) on neuronal firing rats were studied in the limbic system of immobilized cats. Parietal craniotomy was carried out under 1.5--4.0% halothane. Extracellular potentials from single cells in the cingulate gyrus, septum and lateral hypothalamic areas(More)
During an eight-year period, twenty-four Southwick osteotomies were performed in twenty-one patients with severe chronic slipped capital femoral epiphysis. After follow-ups ranging from two to ten years (average, four and one-half years), correction of the deformity had been maintained in all but one patient, who has loss of fixation of the osteotomy. One(More)