Learn More
OBJECTIVES We developed and internally validated a risk score to predict in-hospital stroke or death after carotid artery stenting (CAS). BACKGROUND A tool that accurately assesses CAS risk could aid clinical decision making and improve patient selection. METHODS Patients undergoing CAS without acute evolving stroke from April 2005 through June 2011 as(More)
OBJECTIVE To systematically examine discontinuation rates with new US Food and Drug Administration-approved oral anticoagulants (NOACs) in patients with various indications for long-term anticoagulation. PATIENTS AND METHODS Poor adherence to medications is considered a potential and frequent cause of treatment failure. We searched the PubMed, Cochrane(More)
BACKGROUND Recent studies have suggested that transcatheter aortic valve replacement (TAVR) may have superior outcomes compared with aortic valve replacement (AVR) for high-risk patients with significant mitral regurgitation (MR). Considering significant MR is frequently addressed with a mitral valve repair or replacement (MVR) at the time of open aortic(More)
IMPORTANCE Thrombolytic therapy may be beneficial in the treatment of some patients with pulmonary embolism. To date, no analysis has had adequate statistical power to determine whether thrombolytic therapy is associated with improved survival, compared with conventional anticoagulation. OBJECTIVE To determine mortality benefits and bleeding risks(More)
BACKGROUND Supra-normal ankle brachial index (ABI) (>1.40), poses diagnostic challenges to determine the presence, location, and severity of peripheral artery disease (PAD). The anatomic distribution of PAD in patients with elevated ABI has not been previously described. METHODS A retrospective review of all patients referred to the Massachusetts General(More)
OBJECTIVES We determined whether statin use (vs. non-use) is associated with less annual decline in lower-extremity functioning in patients with and without lower-extremity peripheral arterial disease (PAD) over three-year follow-up. BACKGROUND It is unclear whether statin use is associated with less functional decline in patients with PAD. METHODS(More)
BACKGROUND Renal artery stent revascularization is commonly used for renovascular hypertension. Clinical predictors associated with blood pressure (BP) improvement after renal artery stent revascularization are not well understood. METHODS Patient-level data from 901 patients in five prospective multicenter Food and Drug Administration-approved(More)
BACKGROUND Remote ischemic preconditioning (RIPC) has been associated with reduced risk of myocardial injury in patients undergoing cardiovascular surgery, but uncertainty about clinical outcomes remains, particularly in the light of 2 recent large randomized clinical trials (RCTs) which were neutral. We performed a meta-analysis to evaluate the efficacy of(More)
BACKGROUND A meta-analysis was performed to evaluate the risk of major bleeding with the use of New Oral Anticoagulants (NOACs). METHODS Randomized controlled trials (RCTs) comparing NOACs (rivaroxaban, dabigatran, apixaban, edoxaban and darexaban) with comparators were selected. RESULTS Fifty trials included 155,537 patients. Pooled analysis of all(More)