Jay E. Steele

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A quantitative study has been made of the number of neurofibrillary tangles and of the choline acetyltransferase activity in several sites in the cerebral hemispheres of eight patients who had had Alzheimer's disease. The neurofibrillary tangles were maximal in structures in the medial temporal lobe (uncus, amygdala, hippocampus and parahippocampal gyrus),(More)
The binding of [3H]MK-801 to the N-methyl-D-aspartate receptor complex of well-washed cortical membranes from brains of examples of Alzheimer's disease and controls has been determined in incubations containing either glutamate or glycine plus glutamate. No changes were detected in the IC50 values for inhibition by zinc in the Alzheimer's samples compared(More)
Localization and other studies of glutamatergic receptors are hampered, in part, as pyramidal neurons in the neocortex cannot yet be selectively destroyed in laboratory animals. Demonstration of glutamatergic neuron dysfunction in Alzheimer's disease may allow verification of a technique suitable for the study of these cells in disorders without(More)
A new technique for rendering convective clouds is suggested. The technique uses two lattice-Boltzmann (LB) models, one for generating the spatial and temporal distribution of water density and the other for photon transport , that is, lighting the water density with correct anisotropic scattering. The common LB structure is easily mapped to parallel(More)
Numerical solution of any large, three-dimensional fluid flow problem is a computationally intensive task that typically requires supercomputer solution to achieve reasonable execution time. This paper describes an alternative approach, a technique for mapping three-dimensional fluid flow models to low-cost, desktop hardware. The approach is shown to(More)
Increasing age is associated with increased risk of developing both dementia and depression; both conditions appear to be associated with structural changes in the cerebral cortex. In depression, there was evidence for regional alterations in cortical neurons either as a result of the disease or its treatment. In Alzheimer's disease, a key change is likely(More)
Real-time cinematic relighting of large, forest ecosystems remains a challenging problem, in that important global illumination effects , such as leaf transparency and inter-object light scattering, are difficult to capture, given tight timing constraints and scenes that typically contain hundreds of millions of primitives. A solution that is based on a(More)
This paper presents a simple and efficient algorithm for achieving real-time performance on current consumer graphics hardware when rendering complex, dynamic scenes with direct and secondorder diffuse (indirect) illumination. An image space, low-discrepancy sampling technique for positioning point lights is presented. These point lights simulate(More)