Javier Zorrilla de San Martín

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Bone is a complex tissue that provides mechanical support for muscles and joints, protection for vital organs, a mineral reservoir that is essential for calcium homeostasis, and the environment and niches required for haematopoiesis. The regulation of bone mass in mammals is governed by a complex interplay between bone-forming cells termed osteoblasts and(More)
UNLABELLED An 18-month randomized double-blind study was conducted in postmenopausal women with osteoporosis to compare the effects of once-daily teriparatide 20 microg with alendronate 10 mg on bone histomorphometry. Biopsies were obtained from 42 patients. Indices of bone formation were significantly higher after 6 or 18 months of teriparatide compared(More)
A case of solitary eosinophilic granuloma of the temporal lobe is reported and compared with seven previously documented cases. Long-term clinical follow-up information was obtained on two cases that were originally reported in 1977 and 1981. Solitary eosinophilic granuloma of the cerebral hemisphere, a rare manifestation of Langerhans cell histiocytosis,(More)
The efferent synaptic specialization of hair cells includes a near-membrane synaptic cistern, whose presence suggests a role for internal calcium stores in cholinergic inhibition. Calcium release channels from internal stores include ‘ryanodine receptors’, whose participation is usually demonstrated by sensitivity to the eponymous plant alkaloid, ryanodine.(More)
The efficacy of a screening procedure for detecting nonorganic hearing loss using standard audiometric instrumentation was examined. Thirty normal-hearing subjects' responses to continuous and standard and lengthened off-time pulsed tones, using an ascending-descending method, were compared. Subjects were asked to respond to test stimuli in normal-hearing(More)
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