Javier Velázquez-Moctezuma

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The association between smoking and depression has been widely investigated. Most of these reports suggest that nicotine (NIC) may act as an antidepressant. To examine the suggested antidepressant effect of nicotine and its possible interaction with the serotonergic system, we assessed the effect of nicotine and fluoxetine (FLX) in an animal model of(More)
Chronic exposure to stressors increases HPA axis activity and concomitantly reduces HPG axis activity. This antagonistic relationship between both these axes has been proposed to underlie the inhibition of reproductive function due to stress. Sexual behavior in males may be the most vulnerable aspect of male reproduction to acute and chronic stress and it(More)
An antidepressant action of nicotine (NIC) has recently been suggested. Flouxetine, a selective serotonin reuptake inhibitor, is currently the most widely used antidepressant. In the present study, we analyzed the effects of the administration of NIC, fluoxetine (FLX), and the combination of both drugs given acutely, subchronically, and chronically as well(More)
Plasmatic levels of corticosterone display a circadian rhythm, with the higher values occurring during the dark phase in nocturnally feeding animals. Stressful situations induce a rise of corticosterone levels and this endocrine response to stress also presents circadian variations. The higher increase of corticosterone in response to stress occurs when the(More)
The functions of rapid eye movement (REM) sleep have remained elusive since more than 50 years. Previous reports have identified several independent processes affected by the loss and subsequent recovery of REM sleep (hippocampal neurogenesis, brain stem neuronal cell death, and neurotransmitter content in several brain regions); however, a common(More)
Knowledge concerning the impact of stressful situations on the sleep-wake pattern has been growing rapidly in the last decade. Immobilization (IMB) in rats elicits a significant increase of rapid eye movement (REM) sleep during the following 10 h. Participation of the adrenergic system has been clearly shown in this effect. On the other hand, it is well(More)
It is well known that testosterone (T) plays a major role in the adequate expression of male sexual behavior. On the other hand, the stimulation of central muscarinic receptors with oxotremorine (OXO), a specific agonist, facilitates the expression of masculine sexual behavior in rats. In this study, we analyzed the relationship between T and the(More)
To determine the relationship between the Epworth Sleepiness Scale (ESS) and the Subjective Sleep Quality (SSQ) or polysomnographic (PSG) features in patients with sleep-disordered breathing (SDB). This is a retrospective study that included 646 untreated patients with a PSG diagnosis of primary snoring (PS) or obstructive sleep apnea syndrome. Patients(More)
In this study, the role of cholinergic systems in the regulation of male sexual behavior was analyzed by different approaches. Both muscarinic agonists and antagonists, as well as a nicotine agonist, were administered to sexually experienced male rats. In Experiment 1, oxotremorine (OXO), a muscarinic agonist, decreased the intromission frequency and(More)
Neonatal administration of clomipramine (CMI) in rats induces behavioral changes during adulthood, such as impairments of pleasure-seeking behaviors. However, the endocrine changes induced by this treatment are controversial. In the present study, we analyzed the levels of corticosterone and testosterone in rats neonatally treated with CMI in response to(More)