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Antiviral monoclonal antibodies (mAbs) represent promising therapeutics. However, most mAbs-based immunotherapies conducted so far have only considered the blunting of viral propagation and not other possible therapeutic effects independent of virus neutralization, namely the modulation of the endogenous immune response. As induction of long-term antiviral(More)
Not all T cells specific for autoantigens are eliminated in the thymus, and therefore alternate mechanisms are required to prevent potentially autoreactive T cells from developing into effectors. Adoptive transfer of CD8(+) T cells from influenza hemagglutinin-specific Clone 4 TCR transgenic mice into mice that express hemagluttinin in the pancreatic islets(More)
Hot flashes are experienced by over 70% of menopausal women. Criteria to classify hot flashes from physiologic signals show variable performance. The primary aim was to compare conventional criteria to Support Vector Machines (SVMs), an advanced machine learning method, to classify hot flashes from sternal skin conductance. Thirty women with > or =4 hot(More)
This work explores the feasibility of using motion-sensitive sensors embedded in Google Glass, a head-mounted wearable device, to robustly measure physiological signals of the wearer. In particular, we develop new methods to use Glass's accelerometer, gyroscope, and camera to extract pulse and respiratory waves of 12 participants during a controlled(More)
OBJECTIVE Metformin and statins have shown promise for cancer prevention. This study assessed whether the effect of metformin on prostate cancer (PCa) incidence varied by statin use among type 2 diabetic patients. RESEARCH DESIGN AND METHODS The study cohort consisted of 5,042 type 2 diabetic male patients seen in the Veteran Administration Health Care(More)
BACKGROUND Lymphopenia results in the proliferation and differentiation of naïve T cells into memory-like cells in the apparent absence of antigenic stimulation. This response, at least in part due to a greater availability of cytokines, is thought to promote anti-self responses. Although potentially autoreactive memory-like CD8(+) T cells generated in a(More)
Aberrant DNA methylation at promoters is often linked to tumorigenesis. But many aspects of DNA methylation remain unexplored, including the individual roles of distal and gene body methylation, as well as their collaborative roles with promoter methylation. Here we performed a MBD-seq analysis on prostate specimens classified into low, high, and very high(More)
Most midlife women have hot flashes. The conventional criterion (≥2 μmho rise/30 s) for classifying hot flashes physiologically has shown poor performance. We improved this performance in the laboratory with Support Vector Machines (SVMs), a pattern classification method. We aimed to compare conventional to SVM methods to classify hot flashes in the(More)
Prostate cancer is one of the most complex and enigmatic oncologic problems in medicine. It is highly prevalent, particularly in elderly males. Unfortunately, its generally protracted and variable clinical course and high association with treatment-related morbidity raise serious questions about the ideal treatment strategy for the individual patient. 5(More)
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