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Rab22a Regulates the Sorting of Transferrin to Recycling Endosomes
TLDR
It is speculated that Rab22a controls the transport of the transferrin receptor from sorting to recycling endosomes and depletion by small interfering RNA disorganized the perinuclear recycling center and strongly inhibited transferrin recycling. Expand
Transmembrane Domain Determinants of CD4 Downregulation by HIV-1 Vpu
TLDR
The identification of Trp22 in the Vpu TMD and Gly415 in the CD4 TMD as critical determinants of Vpu-induced targeting of CD4 to endoplasmic reticulum (ER)-associated degradation (ERAD) is reported. Expand
Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex
TLDR
The crystal structure at 1.7 Å resolution of the mouse Vps54 C-terminal fragment harboring leucine-967, in conjunction with comparative sequence analysis, reveals that Vps 54 has a continuous α-helical bundle organization similar to that of other multisubunit tethering complexes. Expand
Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin.
Despite extensive ex vivo investigation, the spatiotemporal organization of immune cells interacting with virus-infected cells in tissues remains uncertain. To address this, we used intravitalExpand
Multilayered Mechanism of CD4 Downregulation by HIV-1 Vpu Involving Distinct ER Retention and ERAD Targeting Steps
TLDR
It is found that CD4 degradation induced by Vpu is dependent on a key component of the ERAD machinery, the VCP-UFD1L-NPL4 complex, as well as on SCFβ-TrCP-dependent ubiquitination of the CD4 cytosolic tail on lysine and serine/threonine residues. Expand
Ang2/Fat-Free Is a Conserved Subunit of the Golgi-associated Retrograde Protein Complex
TLDR
The protein Ang2 is shown to be a conserved component of the Golgi-associated Retrograde Protein (GARP) complex in higher eukaryotes, contributing to the maintenance of acid hydrolase sorting, lysosome function and autophagy. Expand
Structural Basis for the Recognition of Tyrosine-based Sorting Signals by the μ3A Subunit of the AP-3 Adaptor Complex*
TLDR
The crystal structure of the C-terminal domain of the μ3 subunit of AP-3 (isoform A) in complex with a peptide encoding a YXXØ signal (SDYQRL) from the trans-Golgi network protein TGN38 is solved and the identification of theμ3A site is confirmed, which exhibits similarities and differences that account for the ability of both proteins to bind distinct sets of Y XXØ signals. Expand
Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus.
TLDR
Observations indicate that Rab22a can affect the trafficking from endosomes to the Golgi apparatus probably by promoting fusion among endosome and impairing the proper segregation of membrane domains required for targeting to the trans-Golgi network (TGN). Expand
Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs
TLDR
The primerID method of error-correcting viral population sequencing is utilized to reveal an unexpected role for hemagglutinin (HA) glycosylation in compensating for fitness defects resulting from escape from anti-HA neutralizing antibodies. Expand
Influenza A Virus Negative Strand RNA Is Translated for CD8+ T Cell Immunosurveillance
TLDR
Both the translation of sequences on the negative strand of a single-stranded RNA virus and its relevance in antiviral immunosurveillance are demonstrated. Expand
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