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Achieving Lean Design Process: Improvement Methodology
An improvement methodology is proposed for the design process in construction projects. Based on concepts and principles of lean production, the methodology considers the design process as a set ofExpand
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Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway.
The molecular hallmarks of inflammation-mediated lung carcinogenesis have not been fully clarified, mainly due to the scarcity of appropriate animal models. We have used a silica-induced multistepExpand
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Silica-induced chronic inflammation promotes lung carcinogenesis in the context of an immunosuppressive microenvironment.
The association between inflammation and lung tumor development has been clearly demonstrated. However, little is known concerning the molecular events preceding the development of lung cancer. InExpand
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New syngeneic inflammatory‐related lung cancer metastatic model harboring double KRAS/WWOX alterations
New mouse models with specific drivers of genetic alterations are needed for preclinical studies. Herein, we created and characterized at the genetic level a new syngeneic model for lung cancer andExpand
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The genetic profile of bone marrow transplant patients in different samples of forensic interest
Humans constantly lose epithelial cells, and these biological traces are frequently studied in the context of criminal investigations. The objective of this work was to examine the genetic profile inExpand
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Urologic Pathology: Poster#310 COLLAGEN, TYPE XI, ALPHA 1 IS EXPRESSED IN NEOPLASTIC CELLS WITH SARCOMATOID TRANSFORMATION IN RENAL CELL CARCINOMA
Background: Clear cell carcinoma (CCC) is the most prevalent malignancy of the kidney. Sarcomatoid differentiation can occur in all others histologic subtypes, and it is associated with a significantExpand
Urologic Pathology: Poster#311 COLLAGEN, TYPE XI, ALPHA 1 NEW MARKER OF MUSCULARIS PROPRIA INFILTRATION IN BLADDER CANCER
Background: Bladder cancer is one of the most prevalent neoplasias; although it does not have a high mortality, its great incidence causes a large number of deaths. This is why a proper diagnosis isExpand
Factores modificadores del fenotipo en la miocardiopatía hipertrófica
He leı́do con gran interés el artı́culo publicado en la Revista por Pérez-Sánchez et al.. En este artı́culo se pone de manifiesto que la expresión fenotı́pica de la miocardiopatı́a hipertrófica (MCH)Expand