Javier Fabra

Learn More
Eosinophilic infiltration of the respiratory mucosa is considered an inflammatory hallmark of allergic rhinitis, bronchial asthma and nasal polyposis. However, the mechanisms involved in this infiltration have not yet been totally elucidated. The objective of this study was to investigate and compare the influence of epithelial cell secretions from both(More)
We investigated the effect of budesonide and nedocromil sodium on the secretion of IL-6 and IL-8 by cultured epithelial cells from healthy nasal mucosa and nasal polyps. Human epithelial cell conditioned media was generated with fetal calf serum (FCS) in the presence or absence of budesonide and/or nedocromil sodium. Budesonide inhibited FCS-induced IL-6(More)
In terms of functional treatment of sinonasal pathologies, endoscopic surgery represents a spectacular advance, offering excellent illumination, views of areas previously impossible to monitor, and the ability to view the main reference points in the surgical field. Over a five-year period (1988-1993), the authors have performed 278 paranasal sinus(More)
OBJECTIVE To evaluate the relation between nasal resistance and tolerance and compliance with continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea/hypopnea syndrome (SAHS). MATERIAL AND METHOD One hundred twenty-five patients with a mean apnea/hypopnea index (AHI) of 53 21 were assessed for nasal resistance by active(More)
The activities developed by a company (business processes) have to change frequently to adapt to the environment. The implementation of business processes should support these changes without any receding. In this work, we provide with an approach for modelling and executing agile and adaptable business processes. Our approach is based on UML2 separating(More)
BACKGROUND Eosinophil infiltration is a hallmark of the inflammatory response in rhinitis and in nasal polyposis. OBJECTIVE We studied the effect of steroids and nedocromil sodium on eosinophil survival primed by epithelial cells from healthy (nasal mucosa) and inflamed (nasal polyp) respiratory tissue. METHODS Blood eosinophils were incubated with(More)
The AA. expose their experience drawn out from 150 cases of naso-sinusal pathology, treated through endoscopic surgery after the Messerklinger-Stammberger technique. They emphasize either the advantages of the procedure, in comparison with the classic methods, and the postoperative pitfalls. This procedure call for an exact knowledge of the endoscopic(More)