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An emerging viewpoint is that the CNS uses synergies to simplify the control of the hand. Previous work has shown that static hand postures for mimed grasps can be described by a few principal components in which the higher order components explained only a small fraction of the variance yet provided meaningful information. Extending that earlier work, this(More)
This study examined the directional modulation of dorsal premotor (PMd) cells as a function of time in an instructed delay, reaching task that systematically varied direction and accuracy constraints. In two monkeys, the activity of 150 PMd cells was recorded and the preferred direction (PD) of the firing as a function of time, the PD trajectory, was(More)
The endpoint accuracy of a reaching movement strongly affects kinematics, particularly during the final phases of movement. However, where and how accuracy is represented in the central nervous system remains unknown. In this study, the discharge of 150 neurons located primarily in the dorsal premotor cortex (PMd), were recorded from monkeys performing an(More)
This study has begun to test the hypothesis that aspects of hand/object shape are represented in the discharge of primary motor cortex (M1) neurons. Two monkeys were trained in a visually cued reach-to-grasp task, in which object properties and grasp forces were systematically varied. Behavioral analyses show that the reach and grasp force production were(More)
Rabies has been an enigmatic disease of the nervous system because microscopic findings in the brain tissue are not paralleled by the severity of the clinical illness. The calcium binding protein calbindin (CB) is a neuronal marker of great interest in neuroanatomy and neuropathology. CB-ir neurons in the striatum and cerebral cortex are gabaergic cells. In(More)
INTRODUCTION The neurological signs of rabies are very dramatic. Nevertheless, the infected brain manifests only very subtle histological changes. OBJECTIVE The neuronal morphology in the cerebral cortex of rabies-infected mice was examined by means the Golgi technique for detection of neuropathy. MATERIALS AND METHODS Two groups of mice were inoculated(More)
Alteraciones de la morfología dendrítica neuronal en la corteza cerebral de ratones infectados con rabia: un estudio con la técnica de Golgi Neuronal dentritic morphology alterations in the cerebral cortex of rabies-infected mice: a Golgi study Introduction. The neurological signs of rabies are very dramatic. Nevertheless, the infected brain manifests only(More)
Some clinical features of rabies and experimental evidence from cell culture and laboratory animals suggest impairment of gabaergic neurotransmission. Several types of gabaergic neurons occur in the cerebral cortex. They can be identified by three neuronal markers: the calcium binding proteins (CaBPs) parvalbumin (PV), calbindin (CB) and calretinin (CR).(More)
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