Javier Cristancho Castañeda

Learn More
AIMS The mechanisms involved in hypoxic pulmonary vasoconstriction (HPV) are not yet fully defined. The aim of the study was to determine the role of protein kinase C zeta (PKCzeta) and neutral sphingomyelinase (nSMase) in HPV. METHODS AND RESULTS Ceramide content was measured by immunocytochemistry and voltage-gated potassium channel (KV) currents were(More)
BACKGROUND Many patients with advanced type 2 diabetes do not meet their glycated haemoglobin targets and randomised controlled studies comparing the efficacy of pump treatment and multiple daily injections for lowering glucose in insulin-treated patients have yielded inconclusive results. We aimed to resolve this uncertainty with a randomised controlled(More)
BACKGROUND In insulin-requiring type 2 diabetes patients, current insulin therapy approaches such as basal-alone or basal-bolus multiple daily injections (MDI) have not consistently provided achievement of optimal glycemic control. Previous studies have suggested a potential benefit of continuous subcutaneous insulin infusion (CSII) in these patients. The(More)
BACKGROUND The OpT2mise randomized trial was designed to compare the effects of continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI) on glucose profiles in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Patients with glycated hemoglobin (HbA1c) levels of ≥8% (64 mmol/mol) and ≤12% (108 mmol/mol) despite insulin(More)
Revisión de varios métodos para modelar tiempo a múltiples eventos por sujeto: modelamiento de tiempo a hospitalizaciones y muerte Abstract During the disease-recovery process of many diseases, such as in Heart Failure (HF), often more than one type of event plays a role. Some clinical trials use the combined endpoint of death and a secondary event; for(More)
Rationale: Cigarette smoke (CS) and chronic hypoxia (CH) can produce pulmonary hypertension. Similarities and differences between both exposures and their interaction have not been explored. Objective: Investigate the effects of CS and CH, as single factors or in combination, on the pulmonary circulation in the guinea pig. Methods: Fifty-one guinea pigs(More)
  • 1