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The flow of information from calcium-mobilizing receptors to nuclear factor of activated T cells (NFAT)-dependent genes is critically dependent on interaction between the phosphatase calcineurin and the transcription factor NFAT. A high-affinity calcineurin-binding peptide was selected from combinatorial peptide libraries based on the calcineurin docking(More)
In the Peruvian Amazon, paca meat is consumed by humans. To determine human risk for polycystic echinococcosis, we examined wild pacas from 2 villages; 15 (11.7%) of 128 were infected with Echinococcus vogeli tapeworms. High E. vogeli prevalence among pacas indicates potential risk for humans living in E. vogeli-contaminated areas.
this site, there are probably additional substrate recognition sites. Another contribution to substrate selection is made by scaffold proteins, e.g. AKAP79, which target the phosphatase to neuronal synapses or other cellular sites. Calcineurin also delegates work to protein phosphatase 1 (PP1) through a phosphatase cascade, in which dephosphorylation of the(More)
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