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  • Javier A. Menéndez, Luciano Vellón, +4 authors Ruth Lupu
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2004 (First Publication: 20 July 2004)
  • Fatty acid synthase (FAS) activity is a potential therapeutic target to treat cancer and obesity. Here, we have identified a molecular link between FAS and HER2 (erbB-2) oncogene, a marker for poorExpand
    Transforming Growth Factor-b (TGFb) is a major driving force of the Epithelial-to-Mesenchymal (EMT) genetic program, which becomes overactive in the pathophysiology of many age-related humanExpand
  • Alejandro Vázquez-Martín, Cristina Oliveras-Ferraros, Javier A. Menéndez
  • Biology, Medicine
  • Cell cycle
  • 2009 (First Publication: 1 January 2009)
  • Population studies have revealed that treatment with the anti-diabetic drug metformin significantly associates with reduced breast cancer risk. Animal studies have shown that metformin suppresses theExpand
  • Javier A. Menéndez, Alejandro Vázquez-Martín, +5 authors Antonio Segura-Carretero
  • Biology, Medicine
  • BMC Cancer
  • 2006 (First Publication: 9 May 2007)
  • BackgroundA low incidence of breast cancer in the Mediterranean basin suggests that a high consumption of Extra Virgin Olive Oil (EVOO) might confer this benefit. While the anti-HER2 oncogene effectsExpand
  • Javier A. Menéndez, Luciano Vellón, Ramon Colomer, Ruth Lupu
  • Medicine, Biology
  • Annals of oncology : official journal of the…
  • 2005 (First Publication: 1 March 2005)
  • BACKGROUND The relationship between the intake of olive oil, the richest dietary source of the monounsaturated fatty acid oleic acid (OA; 18:1n-9), and breast cancer risk and progression has become aExpand