Javad Safaei

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BACKGROUND Complex intracellular signaling networks monitor diverse environmental inputs to evoke appropriate and coordinated effector responses. Defective signal transduction underlies many pathologies, including cancer, diabetes, autoimmunity and about 400 other human diseases. Therefore, there is high impetus to define the composition and architecture of(More)
Examiner Date Approved: ii To my father, for his dedication to work To my mother, for her humaneness and optimism To my stepfather, for his critical thinking. iii " Le tact dans l'audace c'est de savoir jusqu'ou on peut aller trop loin " — Jean Cocteau, Le coq et l'arlequin, 1979 iv Acknowledgments I would like to express my gratitude to the following(More)
We know that in logic a predicate is a relation between its arguments. In other words, a predicate defines constraints between its arguments. A predicate ρ(v, r, c) is called selectional restriction where v is a verb, r is a role or an object and c is called a class which is a noun. Selectional preference σ : (v, r, c) → a is a function of these predicates(More)
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