Javad Behboodian

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(-\BSTRACT This paper presents a numerical method for computation of the Fisher information matrix about the five parameters ~1' ~2' p, °1 2 , 022 of two normal distributions. It is shown, by using a simple transformation which reduces the number of parameters from five to three, that the computation of the whole information matrix leads to the numerical(More)
BACKGROUND In clinical trials, both unequal randomization design and sequential analyses have ethical and economic advantages. In the single-stage-design (SSD), however, if the sample size is not adjusted based on unequal randomization, the power of the trial will decrease, whereas with sequential analysis the power will always remain constant. Our aim was(More)
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