Jaume Martin Bosch

Learn More
Batrachochytrium dendrobatidis (Bd) is a globally ubiquitous fungal infection that has emerged to become a primary driver of amphibian biodiversity loss. Despite widespread effort to understand the emergence of this panzootic, the origins of the infection, its patterns of global spread, and principle mode of evolution remain largely unknown. Using(More)
BACKGROUND Patients with cirrhosis in Child-Pugh class C or those in class B who have persistent bleeding at endoscopy are at high risk for treatment failure and a poor prognosis, even if they have undergone rescue treatment with a transjugular intrahepatic portosystemic shunt (TIPS). This study evaluated the earlier use of TIPS in such patients. METHODS(More)
BACKGROUND AND AIMS Our aim was to identify predictors of clinical decompensation (defined as the development of ascites, variceal hemorrhage [VH], or hepatic encephalopathy [HE]) in patients with compensated cirrhosis and with portal hypertension as determined by the hepatic venous pressure gradient (HVPG). METHODS We analyzed 213 patients with(More)
Copyright © 2010 Massachusetts Medical Society. Variceal hemorrhage is a lethal complication of cirrhosis, particularly in patients in whom clinical decompensation (i.e., ascites, encepha­ lopathy, a previous episode of hemorrhage, or jaundice) has already developed. Practice guidelines for the management of varices and variceal hemorrhage1 in cir­ rhosis(More)
BACKGROUND Transient elastography (TE) has received increasing attention as a means to evaluate disease progression in patients with chronic liver disease. AIM To assess the value of TE for predicting the stage of fibrosis. METHODS Liver biopsy and TE were performed in 150 consecutive patients with chronic hepatitis C-related hepatitis (92 men and 58(More)
Continuing advances in the knowledge of the pathophysiology of portal hypertension result in the progressive expansion of the spectrum of drugs with a potential role for clinical practice, with objectives that now tend to include the prevention of the enlargement or even the development of esophageal varices. This systematic review summarizes the evidence(More)
Angiogenesis and disruption of liver vascular architecture have been linked to progression to cirrhosis and liver cancer (HCC) in chronic liver diseases, which contributes both to increased hepatic vascular resistance and portal hypertension and to decreased hepatocyte perfusion. On the other hand, recent evidence shows that angiogenesis modulates the(More)
Eugene Athan,* Anthony M. Allworth,† Catherine Engler,‡ Ivan Bastian,§ and Allen C. Cheng*¶ *The Geelong Hospital, Geelong, Victoria, Australia; †Royal Brisbane Hospital, Brisbane, Queensland, Australia; ‡Queensland Health Pathology Services, Townsville, Queensland, Australia; §Institute of Medical and Veterinary Science, Adelaide, South Australia,(More)
BACKGROUND & AIMS Although resection of hepatocellular carcinoma complicating cirrhosis is restricted to patients with preserved liver function, postoperative hepatic decompensation develops in some patients. The aim of this study was to determine the value of increased portal pressure in the development of postoperative hepatic decompensation. METHODS(More)