Jatan C. Shah

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OROS (melatonin), an oral osmotic system for controlled drug delivery, was evaluated in an open-label, two-way crossover study to test the feasibility of continuous overnight melatonin delivery. Twelve healthy subjects with no sleep disorders, ranging from 60 to 73 years of age, were enrolled in the study. Two doses of melatonin (1 x 110 micrograms and 4 x(More)
This paper presents an event-driven algorithm and its symbolic implementation for the analysis of power and ground bus networks. The algorithm uses frequency domain techniques and moment matching approaches based on Pad e approximants to estimate the transfer function at each node in the P/G network. Afterwards, the transient waveforms are extracted for(More)
The pharmacokinetics and pharmacodynamics of amitriptyline hydrochloride after oral administration of an OROS osmotic system, which provides controlled drug delivery, and an immediate-release (IR) tablet, were evaluated in 24 healthy volunteers after repeated administration for 14 days. Each morning, subjects received either 75 mg of the OROS (amitriptyline(More)
AIMS To characterize the pharmacokinetics of amitriptyline and its metabolite nortriptyline following OROS and IR treatments, and to correlate them with anticholinergic side-effects. METHODS The pharmacokinetics and safety of amitriptyline following administration of an osmotic controlled release tablet (OROS and an immediate release (IR) tablet were(More)
| This paper presents an event-driven algorithm for the symbolic analysis of power and ground bus networks using moment matching techniques to estimate the transfer function at each node in the P/G network. The P/G network is modeled by a hierarchical combination of mesh and tree structures that are composed of a collection of RCsegments and pulldown (or(More)
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