Jasper G. Fokkens

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Many studies have been carried out over the past decades on suppositories and their drug release properties. The present state of knowledge is reviewed with the conclusion that our current understanding of the in vivo performance of suppositories is deficient. It is therefore not possible to rely on in vitro data to predict in vivo performance. Suggestions(More)
In 1992, Dr. J.G. Fokkens, Dr. Y.A. Hekster and Prof. Dr. J.J.C. Scheffer left the Editorial Board. Dr. A.F. Cohen and Dr. H.J. Woerdenbag joined the Editorial Board. In the Editorial Advisory Board Dr. J.P. Delporte (Liege, Belgium) was replaced by Dr. G. Carstens (Hannover, FRG), due to changes in the General Committee of the European Society of Clinical(More)
The rate at which phenobarbital and phenobarbital sodium, suspended in liquid paraffin, are released to buffers pH = 3.0, 7.4 and 10.0 has been studied. The release rate of phenobarbital depends on its solubility and hence on the pH, whereas the initial release rate of phenobarbital sodium is governed by sedimentation and hence is independent of the pH.(More)
The dissolution kinetics of theophylline monohydrate and anhydrous theophylline were investigated with a rotating-disk apparatus in buffer solutions at 298 K under sink conditions. The observed dissolution rate of theophylline monohydrate under various conditions agreed well with predictions based on the Extended Simultaneous Chemical Reaction and(More)
De genoemde FNA-verpakkingen zijn leverbaar door Spruyt-Hillen. De onbedrukte vormen worden op dit moment geleverd in dozen h 60o (I,2 ml) respectievelijk 500 (2,3 ml) strips van I 2 vormen. Binnen afzienbare tijd zullen hiervan echter kleinere verkoopeenheden verkrijgbaar zijn, te weten dozen h 3oo respectievelijk 25o strips. De bedrukte vormen worden(More)
The rate at which phenobarbital and phenobarbital sodium, suspended in liquid paraffin, are released to buffers pH=3.o, 7.4 and 10.0 has been studied. The release rate of phenobarbital depends on its solubility and hence on the pH, whereas the initial release rate of phenobarbital sodium is governed by sedimentation and hence is independent of the pH.(More)
SCHREmER, M., en M. COBEL (I979) (Zur Bedeutung des Kondenswasserabscheiders fiir die wirksame Sterilisation von L6sungen in Blutkonservenflaschen durch gespannten ges~ittigten Wasserdampf, Pharmazie 34, I I7-I I8) beschrijven de wijze waarop hun nieuwe autoclaaf (volgens de daarvoor in de DDR geldende richtlijnen) met sporenaardepakjes wordt onderzocht.(More)
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