Jason Worchel

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Post-traumatic stress disorder (PTSD) is a common and increasingly diagnosed mental illness. Recent pharmacotherapeutic research on treatments for this condition has focused on antidepressant drugs with serotonergic actions. However, the presence of intrusive, psychotic-like symptoms in a substantial portion of PTSD patients raises the possibility that(More)
PURPOSE Our objective was to examine the relative association of depression severity and chronicity, other comorbid psychiatric conditions, and coexisting medical illnesses with multiple domains of health status among primary care patients with clinical depression. METHODS We collected cross-sectional data as part of a treatment effectiveness trial that(More)
BACKGROUND An antipsychotic utilization pattern has evolved substantially over the past 20 years or so due to the introduction of the second-generation antipsychotics (SGAs) and the increasing understanding of their adverse effect profile. OBJECTIVE To understand antipsychotic utilization trends (including monotherapy, antipsychotic switching, and(More)
BACKGROUND AND OBJECTIVE The search for NSAIDs with less gastrointestinal toxicity led to the introduction of the selective cyclo-oxygenase-2 (COX-2) inhibitors. However, following their introduction into the market, concerns have developed regarding their safety, particularly their cardiovascular safety. The purpose of this study was to assess the(More)
BACKGROUND There have been many studies of underadherence to antipsychotics, but antipsychotic overadherence, or medication oversupply, in which patients receive more prescription medications than are needed, has been overlooked. Both underadherence and oversupply can have an important impact on clinical outcomes. OBJECTIVES This study examined adherence(More)
STUDY OBJECTIVES To determine whether the frequency of new-onset diabetes mellitus differs between patients taking atypical antipsychotic agents and those taking typical agents, whether the frequency of new-onset diabetes differs among those taking the atypical antipsychotic agents, and what clinical and demographic factors influence the occurrence of(More)
BACKGROUND Depression frequently occurs in combination with diabetes mellitus, adversely affecting the course of illness. OBJECTIVE To determine whether enhancing care for depression improves affective and diabetic outcomes in older adults with diabetes and depression. DESIGN Preplanned subgroup analysis of the Improving Mood-Promoting Access to(More)
This study examined ischemic reactivity to a psychological stress protocol and whether psychological variables could reliably classify individuals as ischemic reactors. Participants were 54 male Veterans Administration patients who had or were suspected of having CAD. Psychological inventories were administered prior to a psychological stress protocol(More)
OBJECTIVES Most patients with hypertension need combination therapy to reach adequate blood pressure control. The objective of this study was to assess type, duration of, and adherence to antihypertensive therapies among veterans, focusing on the use of combination therapies. RESEARCH DESIGN AND METHODS The design of the study was a retrospective cohort(More)
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