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Our goal is to enable military planners to rapidly critique alternative battle plans by simulating multiple outcomes of adversarial plans. We describe a novel simulator, SimPath, that combines qualitative reasoning, a geographic information system (GIS), and targeted probabilistic calculations to envision how adversarial battle plans can play out. We(More)
The innate immune response is the first line of defense against foreign pathogens. The recognition of virus-associated molecular patterns, including double- and single-stranded RNA, by pattern recognition receptors initiates a cascade of signaling reactions. These result in the transcriptional upregulation and secretion of proinflammatory cytokines that(More)
In microarray experiments, the goal is often to examine many genes, and select some of them for additional investigation. Traditionally, such a selection problem has been formulated as a multiple testing problem. When the genes of interest are genes with unequal distribution of gene expression under different conditions, multiple testing methods provide an(More)
BACKGROUND In genetic transcription research, gene expression is typically reported in a test sample relative to a reference sample. Laboratory assays that measure gene expression levels, from Q-RT-PCR to microarrays to RNA-Seq experiments, will compare two samples to the same genetic sequence of interest. Standard practice is to use the log(2)-ratio as the(More)
We present a multi-phase model of emotions that integrates automatic and fast affective reactions with slower cognitive appraisals to create a final emotional appraisal that is grounded in previous emotional experiences. Affective reactions are the product of an analogical comparison between the current situation and similar cases in memory. This is(More)
Background: Tetra-O-methyl nordihydroguaiaretic acid, also known as terameprocol (TMP), is a naturally occurring phenolic compound found in the resin of the creosote bush. We have shown previously that TMP will suppress production of certain inflammatory cytokines, chemokines and lipids from macrophages following stimulation with LPS or infection with H1N1(More)