Jason W. H. Lee

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A computerized information-gathering system has been developed at The University of Texas Health Science Center at Dallas for otolaryngologic head and neck surgery. Surgeons enter data on operations by answering multiple-choice questions at computer terminals situated near the operating rooms of each hospital. The system's main functions are to ensure(More)
Vaccine delivery systems based on display of antigens on bioengineered bacterial polyester inclusions can stimulate cellular immune responses. The food-grade Gram-positive bacterium Lactococcus lactis was engineered to produce spherical polyhydroxybutyrate (PHB) inclusions which abundantly displayed the hepatitis C virus core (HCc) antigen. In mice, the(More)
The tuberculin skin test for diagnosing tuberculosis (TB) in cattle lacks specificity if animals are sensitized to environmental mycobacteria, as some antigens in purified protein derivative (PPD) prepared from Mycobacterium bovis are present in nonpathogenic mycobacteria. Three immunodominant TB antigens, ESAT6, CFP10, and Rv3615c, are present in members(More)
Ports, warehouses and courier services have to decide online how an arriving task is to be served in order that cost is minimized (or profit maximized). These operators have a wealth of historical data on task assignments; can these data be mined for knowledge or rules that can help the decisionmaking? MOO is a novel application of data mining to online(More)
Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis or Mycobacterium bovis and still remains one of the world's biggest global health burdens. Recently, engineered polyhydroxyalkanoate (PHA) biobeads that were produced in both Escherichia coli and Lactococcus lactis and displayed mycobacterial antigens were found to induce significant(More)
Many bacterial pathogens naturally form cellular inclusions. Here the immunogenicity of polyhydroxyalkanoate (PHA) inclusions and their use as particulate vaccines delivering a range of host derived antigens was assessed. Our study showed that PHA inclusions of pathogenic Pseudomonas aeruginosa are immunogenic mediating a specific cell-mediated immune(More)
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