Jason W Frank

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We have previously shown that a physiological increase in plasma leucine for 60 and 120 min increases translation initiation factor activation in muscle of neonatal pigs. Although muscle protein synthesis is increased by leucine at 60 min, it is not maintained at 120 min, perhaps because of the decrease in plasma amino acids (AA). In the present study, 7-(More)
The rapid growth of neonates is driven by high rates of skeletal muscle protein synthesis. This high rate of protein synthesis, which is induced by feeding, declines with development. Overnight-fasted 7- and 26-day-old pigs either remained fasted or were refed, and the abundance and phosphorylation of growth factor- and nutrient-induced signaling components(More)
The presence of pupillary constriction to darkness is said to be a useful indicator of retinal disease. However, it is also associated with optic nerve disease. The phenomenon has been reported in patients with congenital stationary nightblindness, congenital achromatopsia, bilateral optic neuritis, and dominant optic atrophy. We have observed this response(More)
Seventeen cases of unilateral aphakia secondary to acquired cataracts and dislocated lenses were presented. Final visual acuity was 20/70 or better in 12 of our 17 patients. Binocular single vision has been maintained in four cases. Ten patients had a posttherapy tropia. Early surgery and treatment particularly in the young child is stressed in order to(More)
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