Jason V. Clark

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Early full-term pregnancy is one of the most effective natural protections against breast cancer. To investigate this effect, we have characterized the global gene expression and epigenetic profiles of multiple cell types from normal breast tissue of nulliparous and parous women and carriers of BRCA1 or BRCA2 mutations. We found significant differences in(More)
DNA electroporation has been demonstrated in preclinical models to be a promising strategy to improve cancer immunity, especially when combined with other genetic vaccines in heterologous prime-boost protocols. We report the results of 2 multicenter phase 1 trials involving adult cancer patients (n=33) with stage II-IV disease. Patients were vaccinated with(More)
SUGAR is a nodal analysis package for 3D MEMS simulation that owes its heritage and its name to the SPICE family of circuit simulation. SUGAR has undergone the stage of proof-of-concept which showed that nodal analysis was in fact just as accurate and much faster than nite element simulation on many MEMS problems. The upcoming major release of SUGAR is(More)
Advancements in Sugar include 1) parameterizable netlists, 2) nonlinear frequency response analysis, 3) subnets, 4) improved MNA, 5) reduced order modeling, and 6) a more accurate nonlinear beam model. Examples of these features include the simulation of a two-axis mirror with over 10,000 degrees of freedom, the reduced order modeling applied of an(More)
We propose practical analysis techniques to accurately measure geometric, dynamic, and material properties of MEMS. Analytical methods and test structures are presented to extract over a dozen properties by electric probing in a minimal chip area. Geometric properties include fabrication error with respect to layout geometry such as beam widths, gap(More)
  • J V Clark
  • Journal of neurology, neurosurgery, and…
  • 1970
A 27 year old man had attacks of violence for three years before he died in 1945. Necropsy revealed multiple cavernous angiomata of the brain. This man's daughter died in 1969 at the age of 28 years after a year of intermittent headaches. Necropsy showed a large cavernous angioma in the right temporal lobe. Until now the literature has contained only scanty(More)