Jason Shao

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In this work, we introduce the Growth Curve Analysis Tool (GCAT). GCAT is designed to enable efficient analysis of high-throughput microbial growth curve data collected from cultures grown in microtiter plates. GCAT is accessible through a web browser, making it easy to use and operating system independent. GCAT implements fitting of global sigmoid curve(More)
Selective inhibitors of protein lysine methyltransferases, including SET domain-containing protein 8 (SETD8), are highly desired, as only a fraction of these enzymes are associated with high-quality inhibitors. From our previously discovered SETD8 inhibitor, we developed a more potent analog and solved a cocrystal structure, which is the first crystal(More)
Considerable data suggest that individuals who appear minimally disrupted during an initial drug administration have elevated risk for abusing the drug later. A better understanding of this association could lead to more effective strategies for preventing and treating drug addiction. To investigate this phenomenon using a rigorous experimental model, we(More)
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