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Natural inhibitors of coagulation or inflammation such as the serpins antithrombin (AT), heparin cofactor II (HCII), and alpha(1)-proteinase inhibitor (alpha(1)-PI) can be overwhelmed in thrombosis(More)
BACKGROUND Serpins form a widely distributed protein superfamily, but no integral membrane serpins have been described. OBJECTIVES To anchor three serpins -α(1) -proteinase inhibitor (α(1) PI)(More)
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