Jason R. Wilson

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Ferrets are a useful animal model for human influenza virus infections, since they closely mimic the pathogenesis of influenza viruses observed in humans. However, a lack of reagents, especially for flow cytometry of immune cell subsets, has limited research in this model. Here we use a panel of primarily species cross-reactive antibodies to identify ferret(More)
Humans are often able to generalize knowledge learned from a single exemplar. In this paper, we present a novel integration of mental simulation and analogical generalization algorithms into a cognitive robotic architecture that enables a similarly rudimentary generalization capability in robots. Specifically, we show how a robot can generate variations of(More)
BACKGROUND Vaccines against avian influenza viruses often require high hemagglutinin (HA) doses or adjuvants to achieve serological titers associated with protection against disease. In particular, viruses of the H7 subtype frequently do not induce strong antibody responses following immunization. OBJECTIVES To evaluate whether poor immunogenicity of H7(More)
Moral judgements are a complex phenomenon that have gained a renewed interest in the research community. Many have proposed explanations for moral judgements, including utilitarian accounts and the Principle of Double Effect. Some also advocate for the critical role of emotional processes like empathy. However, developing a computational model of moral(More)
Learning new activities (i.e., sequences of actions possibly involving new objects) from single demonstrations is common for humans and would thus be very desirable for future robots as well. However, “one-shot activity learning” is currently still in its infancy and limited to just recording the observed objects and actions of the human demonstrator. In(More)
Here we define the epitopes on HA that are targeted by a group of 9 recombinant monoclonal antibodies (rmAbs) isolated from memory B cells of mice, immunized by infection with A(H1N1)pdm09 virus followed by a seasonal TIV boost. These rmAbs were all reactive against the HA1 region of HA, but display 7 distinct binding footprints, targeting each of the 4(More)
Much existing work examining the ethical behaviors of robots does not consider the impact and effects of longterm human-robot interactions. A robot teammate, collaborator or helper is often expected to increase task performance, individually or of the team, but little discussion is usually devoted to how such a robot should balance the task requirements(More)
The rising interest in socially assistive robotics is, at least in part, stemmed by the aging population around the world. A lot of research and interest has gone into insuring the safety of these robots. However, little has been done to consider the necessary role of emotion in these robots and the potential ethical implications of having affect-aware(More)
We present a simple, accurate method for computing singular or nearly singular integrals on a smooth, closed surface, such as layer potentials for harmonic functions evaluated at points on or near the surface. The integral is computed with a regularized kernel and corrections are added for regularization and discretization, which are found from analysis(More)
Zoonotic A(H7N9) avian influenza viruses emerged in China in 2013 and continue to be a threat to human public health, having infected over 800 individuals with a mortality rate approaching 40%. Treatment options for people infected with A(H7N9) include the use of neuraminidase (NA) inhibitors. However, like other influenza viruses, A(H7N9) can become(More)